PathWhiz

Pathway Description

Hydrogen Sulfide Biosynthesis I

Escherichia coli

Metabolic Pathway

Many bacteria can produce hydrogen sulfide, which can be used as defense system against antibiotics and oxidative stress. This pathway is one of the hydrogen sulfide biosynthesis pathways (totally two). L-Cysteine is transported by L-cysteine ABC transporter and convert to 3-mercaptopyruvic acid by facilitation of aspartate aminotransferase. 3-Mercaptopyruvic acid is later catalyzed to form pyruvic acid and hydrogen sulfide by 3-mercaptopyruvate sulfurtransferase.

References

Hydrogen Sulfide Biosynthesis I References

Barrett EL, Clark MA: Tetrathionate reduction and production of hydrogen sulfide from thiosulfate. Microbiol Rev. 1987 Jun;51(2):192-205.

Pubmed: 3299028

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		3-Mercaptopyruvic acid
		Adenosine diphosphate
		Adenosine triphosphate
		Hydrogen Ion
		Hydrogen sulfide
		L-Cysteine
		L-Glutamic acid
		Oxoglutaric acid
		Phosphate
		Pyruvic acid
		Water

Visualize Protein Data

		L-cystine ABC transporter - periplasmic binding protein
		3-mercaptopyruvate sulfurtransferase
		Aspartate aminotransferase
		Inner membrane amino-acid ABC transporter permease protein yecS
		Uncharacterized amino-acid ABC transporter ATP-binding protein yecC

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