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Pathway Description
Adenine and Adenosine Salvage III
Escherichia coli
Metabolic Pathway
Adenosine is first incorporated into the cytosol through either a nupG or a nupC transporter. Once in the cytosol, adenosine is degraded into adenine by reacting with a water and a adenosine nucleosidase, releasing a D-ribofuranose and a adenine. The adenine then reacts with a PRPP through a adenine phosphoribosyltransferase resulting in the release of a pyrophosphate and an AMP . The AMP in turn reacts with a water molecule through a AMP nucleosidase resulting in the release of a D-ribofuranose 5-phosphate and a adenine.
References
Adenine and Adenosine Salvage III References
Escherichia coli and Salmonella: Cellular and Molecular Biology (EcoSal). Online edition.
Petersen C, Moller LB: The RihA, RihB, and RihC ribonucleoside hydrolases of Escherichia coli. Substrate specificity, gene expression, and regulation. J Biol Chem. 2001 Jan 12;276(2):884-94. doi: 10.1074/jbc.M008300200.
Pubmed: 11027694
Xi H, Schneider BL, Reitzer L: Purine catabolism in Escherichia coli and function of xanthine dehydrogenase in purine salvage. J Bacteriol. 2000 Oct;182(19):5332-41.
Pubmed: 10986234
Leung HB, Schramm VL: Adenylate degradation in Escherichia coli. The role of AMP nucleosidase and properties of the purified enzyme. J Biol Chem. 1980 Nov 25;255(22):10867-74.
Pubmed: 7000783
Leung HB, Kvalnes-Krick KL, Meyer SL, deRiel JK, Schramm VL: Structure and regulation of the AMP nucleosidase gene (amn) from Escherichia coli. Biochemistry. 1989 Oct 31;28(22):8726-33.
Pubmed: 2690948
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