PathWhiz

Pathway Description

Guanine and Guanosine Salvage

Escherichia coli

Metabolic Pathway

Guanosine can be converted into guanine through a phosphate driven guanosine phosphorylase resulting in the release of an alpha-D-ribose 1 phosphate and a guanine. This compound in turn reacts with a PRPP through a guanine phosphoribosyltransferase resulting in the release of a pyrophosphate and a GMP. Guanosine can also react with and ATP driven guanosine kinase resulting in the release of an ADP, s hydrogen ion and a GMP

References

Guanine and Guanosine Salvage References

Combes A, Lafleuriel J, Le Floc'h F: The inosine-guanosine kinase activity of mitochondria in tubers of Jerusalem artichoke. Plant Physiology & Biochemistry. 1989;27(5):729-736.

Kawasaki H, Shimaoka M, Usuda Y, Utagawa T: End-product regulation and kinetic mechanism of guanosine-inosine kinase from Escherichia coli. Biosci Biotechnol Biochem. 2000 May;64(5):972-9.

Pubmed: 10879466

Gots JS, Benson CE, Shumas SR: Genetic separation of hypoxanthine and guanine-xanthine phosphoribosyltransferase activities by deletion mutations in Salmonella typhimurium. J Bacteriol. 1972 Nov;112(2):910-6.

Pubmed: 4563984

Hammer-Jespersen K, Buxton RS, Hansen TD: A second purine nucleoside phosphorylase in Escherichia coli K-12. II. Properties of xanthosine phosphorylase and its induction by xanthosine. Mol Gen Genet. 1980;179(2):341-8.

Pubmed: 7007809

Escherichia coli and Salmonella: Cellular and Molecular Biology (EcoSal). Online edition.

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		Adenosine diphosphate
		Adenosine triphosphate
		Guanine
		Guanosine
		Guanosine monophosphate
		Hydrogen Ion
		Phosphate
		Phosphoribosyl pyrophosphate
		Pyrophosphate
		Ribose 1-phosphate