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Pathway Description
Guanine and Guanosine Salvage
Escherichia coli
Metabolic Pathway
Guanosine can be converted into guanine through a phosphate driven guanosine phosphorylase resulting in the release of an alpha-D-ribose 1 phosphate and a guanine. This compound in turn reacts with a PRPP through a guanine phosphoribosyltransferase resulting in the release of a pyrophosphate and a GMP.
Guanosine can also react with and ATP driven guanosine kinase resulting in the release of an ADP, s hydrogen ion and a GMP
References
Guanine and Guanosine Salvage References
Combes A, Lafleuriel J, Le Floc'h F: The inosine-guanosine kinase activity of mitochondria in tubers of Jerusalem artichoke. Plant Physiology & Biochemistry. 1989;27(5):729-736.
Kawasaki H, Shimaoka M, Usuda Y, Utagawa T: End-product regulation and kinetic mechanism of guanosine-inosine kinase from Escherichia coli. Biosci Biotechnol Biochem. 2000 May;64(5):972-9.
Pubmed: 10879466
Gots JS, Benson CE, Shumas SR: Genetic separation of hypoxanthine and guanine-xanthine phosphoribosyltransferase activities by deletion mutations in Salmonella typhimurium. J Bacteriol. 1972 Nov;112(2):910-6.
Pubmed: 4563984
Hammer-Jespersen K, Buxton RS, Hansen TD: A second purine nucleoside phosphorylase in Escherichia coli K-12. II. Properties of xanthosine phosphorylase and its induction by xanthosine. Mol Gen Genet. 1980;179(2):341-8.
Pubmed: 7007809
Escherichia coli and Salmonella: Cellular and Molecular Biology (EcoSal). Online edition.
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