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Pathway Description

Pyruvate Decarboxylation to Acetyl-CoA

Escherichia coli

Metabolic Pathway

The multi-enzyme complex catalyze three reactions that constitute a cycle, which is an essential source of acetyl-CoA. Pyruvate dehydrogenase E1 and dihydrolipoyllysine-residue acetyltransferase catalyzes pyruvic acid to acetyl-CoA and CO2. Acetyl-CoA is required for the TCA cycle. Lipoamide dehydrogenase reduces NAD+ to NADH.

References

Pyruvate Decarboxylation to Acetyl-CoA References

de Kok A, Hengeveld AF, Martin A, Westphal AH: The pyruvate dehydrogenase multi-enzyme complex from Gram-negative bacteria. Biochim Biophys Acta. 1998 Jun 29;1385(2):353-66.

Pubmed: 9655933

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