Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Methylglyoxal Degradation II
Escherichia coli
Metabolic Pathway
The most common pathway for methylglyoxal detoxification is the glyoxalase system, which is composed of two enzymes that together convert methylglyoxal to (R)-lactate in the presence of glutathione. However, in E. coli, a single enzyme, glyoxalase III, catalyzes this conversion in a single step without involvement of glutathione. Activity of glyoxalase III increases at the transition to stationary phase and expression is dependent on RpoS, suggesting that this pathway may be important during stationary phase. (EcoCyc)
References
Methylglyoxal Degradation II References
Benov L, Sequeira F, Beema AF: Role of rpoS in the regulation of glyoxalase III in Escherichia coli. Acta Biochim Pol. 2004;51(3):857-60. doi: 045103857.
Pubmed: 15448747
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Settings