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Pathway Description
Cyanate Degradation
Escherichia coli
Metabolic Pathway
The cyanate degradation pathway begins with the transportation of cyanate into the cytosol through a cynX transporter. Once inside the cytosol cyanate reacts with hydrogen carbonate and a hydrogen ion through a cyanase resulting in the release of carbon dioxide and carbamate. Carbamate reacts spontaneously with hydrogen resulting in the release of ammonium and carbon dioxide. Carbon dioxide reacts with water through carbonic anhydrase resulting in the release of hydrogen ion and hydrogen carbonate.
References
Cyanate Degradation References
Guilloton MB, Lamblin AF, Kozliak EI, Gerami-Nejad M, Tu C, Silverman D, Anderson PM, Fuchs JA: A physiological role for cyanate-induced carbonic anhydrase in Escherichia coli. J Bacteriol. 1993 Mar;175(5):1443-51.
Pubmed: 8444806
Kozliak EI, Fuchs JA, Guilloton MB, Anderson PM: Role of bicarbonate/CO2 in the inhibition of Escherichia coli growth by cyanate. J Bacteriol. 1995 Jun;177(11):3213-9.
Pubmed: 7768821
Sung YC, Parsell D, Anderson PM, Fuchs JA: Identification, mapping, and cloning of the gene encoding cyanase in Escherichia coli K-12. J Bacteriol. 1987 Jun;169(6):2639-42.
Pubmed: 3034861
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