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Pathway Description
L-Arabinose Degradation I
Escherichia coli
Metabolic Pathway
L-arabinose enters E. coli unphosphorylated via a low-affinity proton-driven transporter (AraE) or a high-affinity ATP-driven system (AraFGH). Following entry, it is converted to L-ribulose-5-phosphate by an isomerase and kinase. L-ribulose-5-phosphate is then converted by an epimerase to the pentose phosphate pathway intermediate, D-xylulose-5-phosphate. D-xylulose-5-phosphate then enters metabolism pathways to become precursor metabolites, reducing power and metabolic energy.
References
L-Arabinose Degradation I References
Fritz G, Megerle JA, Westermayer SA, Brick D, Heermann R, Jung K, Radler JO, Gerland U: Single cell kinetics of phenotypic switching in the arabinose utilization system of E. coli. PLoS One. 2014 Feb 26;9(2):e89532. doi: 10.1371/journal.pone.0089532. eCollection 2014.
Pubmed: 24586851
Schleif R: Regulation of the L-arabinose operon of Escherichia coli. Trends Genet. 2000 Dec;16(12):559-65.
Pubmed: 11102706
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