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Pathway Description
Lipoate Biosynthesis and Incorporation I
Escherichia coli
Metabolic Pathway
Lipoate is an essential cofactor for key enzymes of oxidative metabolism. Mechanism of lipoate biosynthesis is similar to biotin biosynthesis. Octanoyltransferase facilitates the tranfer of octanoate moiety from octanoate-ACP to particular lysyl residues in lipoate-dependent enzymes. This process regenerates the acyl-carrier in the process, and create an octanylated domains in lipoate-dependent enzymes. Lipoyl synthase combines with S-adenosyl-L-methionine to generate an active lipoylated domain by converting the octanoyl side chain to an active lipoyl. Lipoyl synthase also split S-Adenosyl methionine (AdoMet) into 5'-deoxyadenosyl radical (later becomes 5'-deoxyadenosine by abstracting a hydrogen from a C-H bond) and L-methionine. L-methionine will undergo S-Adenosyl-L-Methionine Biosynthesis.
References
Lipoate Biosynthesis and Incorporation I References
Herbert AA, Guest JR: Lipoic acid content of Escherichia coli and other microorganisms. Arch Microbiol. 1975 Dec 31;106(3):259-66.
Pubmed: 814874
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