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Pathway Description
Asparagine Metabolism
Saccharomyces cerevisiae
Metabolic Pathway
In both eukaryotes and prokaryotes, L-asparagine is biosynthesized from L-aspartate by amidation using L-glutamine as an amino group donor which both of reactions are driven by ATP. In the first reaction, asparagine synthetase [glutamine-hydrolyzing] 1 catalyzes L-aspartic acid to form L-Asparagine. In the second reactions, asparagine synthetase [glutamine-hydrolyzing] 1 and 2 both catalyze L-aspartic acid to form L-Asparagine. Asparagine gets metabolized back into L-aspartic acid by reacting with water through a L-asparaginase 1 resulting in the release of ammonium and L-aspartic acid. The only known role of L-asparagine is incorporation into proteins.
References
Asparagine Metabolism References
ter Schure EG, van Riel NA, Verrips CT: The role of ammonia metabolism in nitrogen catabolite repression in Saccharomyces cerevisiae. FEMS Microbiol Rev. 2000 Jan;24(1):67-83.
Pubmed: 10640599
Jones EW and Fink GR Regulation of amino acid and nucleotide biosynthesis in yeast. in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press (1982) p.181-299
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