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Pathway Description
Aspartate Metabolism
Saccharomyces cerevisiae
Metabolic Pathway
Aspartate (also named as L-aspartic acid) is an α-amino acid that can be used for protein biosynthesis. Oxalacetic acid is produced from aspartic acid by mitochondrial aspartate aminotransferase, then oxalacetic acid is reduced to malic acid by malate dehydrogenase. Malic acid enters mitochondria through mitochondrial dicarboxylate transporter and forms oxalacetic acid by facilitation of malate dehydrogenase. In the final step, oxalacetic acid is catalyzed by mitochondrial aspartate aminotransferase to form aspartate.
References
Aspartate Metabolism References
Cavero S, Vozza A, del Arco A, Palmieri L, Villa A, Blanco E, Runswick MJ, Walker JE, Cerdan S, Palmieri F, Satrustegui J: Identification and metabolic role of the mitochondrial aspartate-glutamate transporter in Saccharomyces cerevisiae. Mol Microbiol. 2003 Nov;50(4):1257-69.
Pubmed: 14622413
Pastore D, Di Pede S, Passarella S: Isolated durum wheat and potato cell mitochondria oxidize externally added NADH mostly via the malate/oxaloacetate shuttle with a rate that depends on the carrier-mediated transport. Plant Physiol. 2003 Dec;133(4):2029-39. doi: 10.1104/pp.103.028548. Epub 2003 Dec 11.
Pubmed: 14671011
Hung GC, Brown CR, Wolfe AB, Liu J, Chiang HL: Degradation of the gluconeogenic enzymes fructose-1,6-bisphosphatase and malate dehydrogenase is mediated by distinct proteolytic pathways and signaling events. J Biol Chem. 2004 Nov 19;279(47):49138-50. doi: 10.1074/jbc.M404544200. Epub 2004 Sep 8.
Pubmed: 15358789
Steffan JS, McAlister-Henn L: Isolation and characterization of the yeast gene encoding the MDH3 isozyme of malate dehydrogenase. J Biol Chem. 1992 Dec 5;267(34):24708-15.
Pubmed: 1447211
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