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Pathway Description
TCA Cycle
Saccharomyces cerevisiae
Metabolic Pathway
Citric acid cycle (also known as tricarboxylic acid cycle (TCA) and Krebs cycle) contains series of reactions that involved enzyme catalyzation which are essential for all living cells that require oxygen for cellular respiration. In mitochondria (for eukaryotes), TCA cycle begins with acetyl-CoA and oxaloacetic acid (oxaloacetate) be catalyzed to form citric acid (citrate) by citrate synthase 3. Then, 3-isopropylmalate dehydratase with cofactor 4Fe-4S can catalyze citrate to form cis-aconitic acid as the intermediate compound and catalyze cis-aconitic acid to form isocitric acid. Many TCA cycle intermediates are the precursors for other molecules' synthesis; and NADH (from NAD+) is the major energy that is produced by oxidative steps of the TCA cycle.
References
TCA Cycle References
Lehninger, A.L. Lehninger principles of biochemistry (4th ed.) (2005). New York: W.H Freeman.
Salway, J.G. Metabolism at a glance (3rd ed.) (2004). Alden, Mass.: Blackwell Pub.
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