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C00315 KEGG Compound 7722-84-1 CAS 6022 PubChem-compound 6262 PubChem-compound 937 ChemSpider CYS BioCyc HMDB0003125 HMDB ReactionCatalysis6219 ACTIVATION ReactionCatalysis6218 ACTIVATION ReactionCatalysis6213 ACTIVATION ReactionCatalysis6212 ACTIVATION ReactionCatalysis6211 ACTIVATION HMDB0000095 HMDB ReactionCatalysis6210 ACTIVATION ReactionCatalysis6217 ACTIVATION HMDB0001185 HMDB ReactionCatalysis6216 ACTIVATION ReactionCatalysis6215 ACTIVATION ReactionCatalysis6214 ACTIVATION 6131 PubChem-compound P53332 UniProt C3H7NO 3-Aminopropanal 73.052765 CHEBI:16027 ChEBI ReactionCatalysis6220 ACTIVATION ATP BioCyc 6137 PubChem-compound ornithine decarboxylase 124-20-9 CAS 559142 ChemSpider ReactionCatalysis6222 ACTIVATION ReactionCatalysis6221 ACTIVATION C15H23N6O5S S-Adenosylmethionine 399.14505 DEPHOSPHO-COA BioCyc 1.0 5742 ChemSpider CHEBI:17561 ChEBI CHEBI:16474 ChEBI C9H18NO8P D-4'-Phosphopantothenate 299.077 952 ChemSpider 439176 PubChem-compound 5858 ChemSpider CHEBI:16240 ChEBI 1010 ChemSpider 388463 ChemSpider Saccharomyces cerevisiae SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS S-AdenosylMethionine requiring PPI BioCyc SMILES NCCCCN 4'-Phosphopantothenoylcysteine 63-37-6 CAS S-adenosylmethionine synthetase CHEBI:17148 ChEBI 1.0 PANTOTHENATE BioCyc 1.0 1.0 SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N Spermine Cytosol 1.0 SMILES CC(C)(COP(O)(O)=O)C(O)C(=O)NCCC(O)=O 1.0 Q03941 UniProt Phosphopantothenoylcysteine decarboxylase subunit SIS2 phosphopantothenate-cysteine ligase C12H23N2O9PS 4'-Phosphopantothenoylcysteine 402.08618 pantothenate kinase Phosphopantothenoylcysteine decarboxylase subunit VHS3 P40459 UniProt Coenzyme A biosynthesis protein 3 Spermine Synthase S-AdenosylMethionine requiring pantoate β-alanine ligase Aldehyde dehydrogenase [NAD(P)+] 2 C00009 KEGG Compound 110-60-1 CAS C00008 KEGG Compound C00007 KEGG Compound dephospho-CoA kinase C00006 KEGG Compound pantetheine-phosphate adenylyltransferase Hydrogen Ion CHEBI:18009 ChEBI C00001 KEGG Compound CTP BioCyc CHEBI:18361 ChEBI 388321 ChemSpider C00005 KEGG Compound CHEBI:18367 ChEBI 1032 ChemSpider NADPH C00002 KEGG Compound Dephospho-CoA pantoate β-alanine ligase P50264 UniProt C00019 KEGG Compound Coenzyme A Coenzyme A biosynthesis protein 3 CHEBI:17361 ChEBI C00011 KEGG Compound C00010 KEGG Compound PW002381 PathWhiz C00013 KEGG Compound C00134 KEGG Compound NAD(P) BioCyc C7H19N3 Spermidine 145.1579 C10H26N4 Spermine 202.21574 H Hydrogen Ion 1.007825 SMILES CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N 1.0 MET BioCyc 56-65-5 CAS C00020 KEGG Compound 5653 ChemSpider C00027 KEGG Compound 1.0 NADP P36076 UniProt C5H11NO2S L-Methionine 149.05106 PUTRESCINE BioCyc 79-83-4 CAS 52-90-4 CAS AMP BioCyc phosphopantothenoylcysteine decarboxylase HYDROGEN-PEROXIDE BioCyc SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O P36024 UniProt HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB S-adenosylmethionine synthetase C01137 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 763 ChemSpider SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O HMDB0001117 HMDB C00170 KEGG Compound 388529 ChemSpider 5901 ChemSpider 1.0 784 PubChem-compound Pantothenic acid (R)-pantoate pantothenate kinase C00055 KEGG Compound 7732-18-5 CAS 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 C00063 KEGG Compound 63-68-3 CAS 5907 ChemSpider C10H16N5O13P3 Adenosine triphosphate 506.99576 HMDB0001256 HMDB HMDB0001377 HMDB HMDB0000045 HMDB HMDB0001016 HMDB 65-47-4 CAS HMDB0001257 HMDB S-adenosylmethionine decarboxylase C00073 KEGG Compound spermidine synthase C14H23N6O3S S-Adenosylmethioninamine 355.15524 ornithine decarboxylase Polyamine oxidase SMILES NCCC(O)=O HMDB0001373 HMDB 3-Aminopropanal 962 PubChem-compound 31983 ChemSpider 5800 ChemSpider C00077 KEGG Compound CO2 Carbon dioxide 43.98983 Hydrogen peroxide CMP BioCyc C00080 KEGG Compound HMDB0000056 HMDB SMILES O=O HMDB0002111 HMDB SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 14265-44-2 CAS 6176 PubChem-compound 58-64-0 CAS S-adenosylmethionine synthetase Putrescine 963 ChemSpider 4'-phosphopantetheine S-adenosylmethionine decarboxylase P40506 UniProt 644102 PubChem-compound C3H7NO2S L-Cysteine 121.01975 4932 TAXONOMY 988 PubChem-compound 5941 ChemSpider 6083 PubChem-compound C00099 KEGG Compound C00097 KEGG Compound C03492 KEGG Compound 22833512 PubChem-compound 1.0 H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 1.0 1.0 977 PubChem-compound HMDB0059597 HMDB SPERMIDINE BioCyc SMILES CC(C(=O)NCCC(=O)NCCS)C(C)(C)COP([O-])([O-])=O 1.0 SMILES CC(C)(CO)C(O)C([O-])=O 1.0 Q08438 UniProt C04352 KEGG Compound HMDB0000082 HMDB HMDB0001173 HMDB CHEBI:15905 ChEBI 7196-09-0 CAS 2457-80-9 CAS 17215925 ChemSpider 71-44-3 CAS SMILES N[C@@H](CS)C(O)=O phosphopantothenate-cysteine ligase Adenosine monophosphate 1.0 Q04430 UniProt SMILES O 13837702 ChemSpider SMILES OO C10H14N5O7P Adenosine monophosphate 347.06308 Q12074 UniProt C6H11O4 (R)-pantoate 147.06628 C12H23N2O6PS 4'-phosphopantetheine 354.10254 239 PubChem-compound HMDB0000538 HMDB 1.0 1.0 S-ADENOSYLMETHIONINAMINE BioCyc 128 ChemSpider 6816 PubChem-compound ADP BioCyc CHEBI:15729 ChEBI C3H7NO2 beta-Alanine 89.047676 6.3.2.5 false 6.3.2.5 Cytidine triphosphate + D-4'-Phosphopantothenate + L-Cysteine → 4'-Phosphopantothenoylcysteine + Cytidine monophosphate + Hydrogen Ion + Pyrophosphate LEFT_TO_RIGHT Reaction6291 false 4'-Phosphopantothenoylcysteine + Hydrogen Ion → 4'-phosphopantetheine + Carbon dioxide LEFT_TO_RIGHT 53-59-8 CAS 2.7.7.3 false 2.7.7.3 4'-phosphopantetheine + Adenosine triphosphate + Hydrogen Ion → Dephospho-CoA + Pyrophosphate LEFT_TO_RIGHT 2.7.1.24 false 2.7.1.24 Adenosine triphosphate + Dephospho-CoA → Adenosine diphosphate + Coenzyme A + Hydrogen Ion LEFT_TO_RIGHT 1038 PubChem-compound R-4-PHOSPHOPANTOTHENOYL-L-CYSTEINE BioCyc SMILES CSCC[C@H](N)C(O)=O GO:0005829 GENE ONTOLOGY 274 ChemSpider 2.5.1.6 false 2.5.1.6 Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine LEFT_TO_RIGHT 2.5.1.22 false 2.5.1.22 S-Adenosylmethioninamine + Spermidine → 5'-Methylthioadenosine + Hydrogen Ion + Spermine LEFT_TO_RIGHT 1.2.1.3 false 1.2.1.3 3-Aminopropanal + NADP + Water → Hydrogen Ion + NADPH + beta-Alanine LEFT_TO_RIGHT 6.3.2.1 false 6.3.2.1 (R)-pantoate + Adenosine triphosphate + beta-Alanine → Adenosine monophosphate + Hydrogen Ion + Pantothenic acid + Pyrophosphate LEFT_TO_RIGHT 1.0 Phosphopantothenoylcysteine decarboxylase subunit SIS2 2.7.1.33 false 2.7.1.33 Adenosine triphosphate + Pantothenic acid ? Adenosine diphosphate + D-4'-Phosphopantothenate + Hydrogen Ion 70-26-8 CAS 1.5.3.17 false 1.5.3.17 Oxygen + Spermine + Water → 3-Aminopropanal + Hydrogen peroxide + Spermidine LEFT_TO_RIGHT 4.1.1.17 false 4.1.1.17 Hydrogen Ion + Ornithine → Carbon dioxide + Putrescine LEFT_TO_RIGHT 2.5.1.16 false 2.5.1.16 Putrescine + S-Adenosylmethioninamine → 5'-Methylthioadenosine + Hydrogen Ion + Spermidine LEFT_TO_RIGHT Pyrophosphate 4.1.1.50 false 4.1.1.50 Hydrogen Ion + S-Adenosylmethionine → Carbon dioxide + S-Adenosylmethioninamine LEFT_TO_RIGHT C9H17NO5 Pantothenic acid 219.11067 O4P Phosphate 94.95342 485-80-3 CAS 6026 ChemSpider 5862 PubChem-compound 131 PubChem-compound P21182 UniProt Cytidine monophosphate HMDB0001414 HMDB C21H30N7O17P3 NADPH 745.0911 75 PubChem-compound C21H29N7O17P3 NADP 744.08325 S-Adenosylmethioninamine C5H12N2O2 Ornithine 132.08987 NADPH BioCyc CHEBI:16610 ChEBI Carbon dioxide CPD-6641 BioCyc HMDB0000574 HMDB HMDB0000210 HMDB HMDB0001423 HMDB HMDB0000696 HMDB 4-P-PANTOTHENATE BioCyc SMILES [O-]P([O-])([O-])=O SMILES CC(C)(CO)[C@@H](O)C(=O)NCCC(O)=O HMDB0000214 HMDB HMDB0000217 HMDB 124-38-9 CAS CHEBI:15414 ChEBI HMDB0001429 HMDB SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB SMILES NCCC[C@H](N)C(O)=O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O beta-Alanine Metabolism CHEBI:15769 ChEBI 107-95-9 CAS 1.0 53-57-6 CAS 1.0 CHEBI:15625 ChEBI CHEBI:15746 ChEBI S-ADENOSYLMETHIONINE BioCyc SMILES O=C=O CHEBI:15980 ChEBI O7P2 Pyrophosphate 173.91193 234 ChemSpider 5957 PubChem-compound C9H16N3O14P3 Cytidine triphosphate 482.9845 439415 PubChem-compound dephospho-CoA kinase 22365-13-5 CAS spermidine synthase 1102 PubChem-compound 1103 PubChem-compound Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 CHEBI:16958 ChEBI CHEBI:61723 ChEBI C9H14N3O8P Cytidine monophosphate 323.05185 SMP0002307 SMPDB CPD-8587 BioCyc 3633-59-8 CAS 440304 PubChem-compound CHEBI:1146900 ChEBI SMILES NCCCCNCCCN SMILES NCCCNCCCCNCCCN 5-METHYLTHIOADENOSINE BioCyc 1.0 14000-31-8 CAS CO-A BioCyc 1072 ChemSpider 1071 ChemSpider 5675 ChemSpider B-ALANINE BioCyc S-Adenosylmethionine Ornithine C21H36N7O16P3S Coenzyme A 767.11523 Adenosine diphosphate SPERMINE BioCyc CHEBI:17509 ChEBI C4H12N2 Putrescine 88.10005 1.0 Spermine Synthase CHEBI:7916 ChEBI P54114 UniProt CHEBI:15422 ChEBI 6557 ChemSpider 1.0 1.0 Polyamine oxidase O2 Oxygen 31.98983 439335 PubChem-compound C21H35N7O13P2S Dephospho-CoA 687.14886 Water CHEBI:16643 ChEBI C00864 KEGG Compound CHEBI:16526 ChEBI 389278 ChemSpider CHEBI:16761 ChEBI 7782-44-7 CAS beta-Alanine 1.0 Q12455 UniProt 1.0 P08432 UniProt L-Methionine C00750 KEGG Compound pantetheine-phosphate adenylyltransferase 5'-Methylthioadenosine Phosphopantothenoylcysteine decarboxylase subunit VHS3 CHEBI:15377 ChEBI CHEBI:17677 ChEBI L-Cysteine CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] C11H15N5O3S 5'-Methylthioadenosine 297.08957 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 1045 PubChem-compound C00882 KEGG Compound Phosphate Oxygen 280 PubChem-compound SMILES C[S+](CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N 1.0 CHEBI:15468 ChEBI Cytidine triphosphate D-4'-Phosphopantothenate HMDB0000988 HMDB 1.0 P10659 UniProt 1.0 SMILES CC(C)(COP(O)(O)=O)[C@@H](O)C(=O)NCCC(=O)N[C@@H](CS)C(O)=O Spermidine 1061 PubChem-compound SMILES NCCC=O HMDB0001967 HMDB 24762165 PubChem-compound Aldehyde dehydrogenase [NAD(P)+] 2 P19358 UniProt 1.0 85-61-0 CAS L-ORNITHINE BioCyc Polyamine oxidase ornithine decarboxylase spermidine synthase S- adenosylmethionine decarboxylase S- adenosylmethionine synthetase S- AdenosylMethionine requiring Spermine Synthase Aldehyde dehydrogenase [NAD(P)+] 2 pantoate β-alanine ligase pantothenate kinase phosphopantothenate- cysteine ligase Coenzyme A biosynthesis protein 3 Phosphopantothenoylcysteine decarboxylase subunit VHS3 Phosphopantothenoylcysteine decarboxylase subunit SIS2 pantetheine- phosphate adenylyltransferase dephospho-CoA kinase Spermine H 2 O O 2 H 2 O 2 3-Aminopropanal Spermidine Ornithine H + CO 2 Putrescine S- Adenosylmethioninamine H + 5'- Methylthioadenosine Spermidine S- Adenosylmethionine H + CO 2 L-Methionine ATP H 2 O P i PP i S- Adenosylmethioninamine H + 5'- Methylthioadenosine Spermine H 2 O NADP beta-Alanine H + NADPH (R)-pantoate ATP Pantothenic acid AMP PP i H + ATP D-4'- Phosphopantothenate ADP H + Cytidine triphosphate L-Cysteine Cytidine monophosphate PP i H + 4'- Phosphopantothenoylcysteine H + CO 2 4'- phosphopantetheine ATP H + PP i Dephospho-CoA ATP H + ADP Coenzyme A
C00315 KEGG Compound 7722-84-1 CAS 6022 PubChem-compound 6262 PubChem-compound 937 ChemSpider CYS BioCyc HMDB0003125 HMDB ReactionCatalysis6219 ACTIVATION ReactionCatalysis6218 ACTIVATION ReactionCatalysis6213 ACTIVATION ReactionCatalysis6212 ACTIVATION ReactionCatalysis6211 ACTIVATION HMDB0000095 HMDB ReactionCatalysis6210 ACTIVATION ReactionCatalysis6217 ACTIVATION HMDB0001185 HMDB ReactionCatalysis6216 ACTIVATION ReactionCatalysis6215 ACTIVATION ReactionCatalysis6214 ACTIVATION 6131 PubChem-compound P53332 UniProt C3H7NO 3-Aminopropanal 73.052765 CHEBI:16027 ChEBI ReactionCatalysis6220 ACTIVATION ATP BioCyc 6137 PubChem-compound ornithine decarboxylase 124-20-9 CAS 559142 ChemSpider ReactionCatalysis6222 ACTIVATION ReactionCatalysis6221 ACTIVATION C15H23N6O5S S-Adenosylmethionine 399.14505 DEPHOSPHO-COA BioCyc 1.0 5742 ChemSpider CHEBI:17561 ChEBI CHEBI:16474 ChEBI C9H18NO8P D-4'-Phosphopantothenate 299.077 952 ChemSpider 439176 PubChem-compound 5858 ChemSpider CHEBI:16240 ChEBI 1010 ChemSpider 388463 ChemSpider Saccharomyces cerevisiae SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)(O)=O)N1C=NC2=C1N=CN=C2N)[C@@H](O)C(=O)NCCC(=O)NCCS S-AdenosylMethionine requiring PPI BioCyc SMILES NCCCCN 4'-Phosphopantothenoylcysteine 63-37-6 CAS S-adenosylmethionine synthetase CHEBI:17148 ChEBI 1.0 PANTOTHENATE BioCyc 1.0 1.0 SMILES C[S+](CC[C@H](N)C(O)=O)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N Spermine Cytosol 1.0 SMILES CC(C)(COP(O)(O)=O)C(O)C(=O)NCCC(O)=O 1.0 Q03941 UniProt Phosphopantothenoylcysteine decarboxylase subunit SIS2 phosphopantothenate-cysteine ligase C12H23N2O9PS 4'-Phosphopantothenoylcysteine 402.08618 pantothenate kinase Phosphopantothenoylcysteine decarboxylase subunit VHS3 P40459 UniProt Coenzyme A biosynthesis protein 3 Spermine Synthase S-AdenosylMethionine requiring pantoate β-alanine ligase Aldehyde dehydrogenase [NAD(P)+] 2 C00009 KEGG Compound 110-60-1 CAS C00008 KEGG Compound C00007 KEGG Compound dephospho-CoA kinase C00006 KEGG Compound pantetheine-phosphate adenylyltransferase Hydrogen Ion CHEBI:18009 ChEBI C00001 KEGG Compound CTP BioCyc CHEBI:18361 ChEBI 388321 ChemSpider C00005 KEGG Compound CHEBI:18367 ChEBI 1032 ChemSpider NADPH C00002 KEGG Compound Dephospho-CoA pantoate β-alanine ligase P50264 UniProt C00019 KEGG Compound Coenzyme A Coenzyme A biosynthesis protein 3 CHEBI:17361 ChEBI C00011 KEGG Compound C00010 KEGG Compound PW002381 PathWhiz C00013 KEGG Compound C00134 KEGG Compound NAD(P) BioCyc C7H19N3 Spermidine 145.1579 C10H26N4 Spermine 202.21574 H Hydrogen Ion 1.007825 SMILES CSC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N 1.0 MET BioCyc 56-65-5 CAS C00020 KEGG Compound 5653 ChemSpider C00027 KEGG Compound 1.0 NADP P36076 UniProt C5H11NO2S L-Methionine 149.05106 PUTRESCINE BioCyc 79-83-4 CAS 52-90-4 CAS AMP BioCyc phosphopantothenoylcysteine decarboxylase HYDROGEN-PEROXIDE BioCyc SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O P36024 UniProt HMDB0000250 HMDB SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB S-adenosylmethionine synthetase C01137 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 763 ChemSpider SMILES NC1=NC(=O)N(C=C1)[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]1O HMDB0001117 HMDB C00170 KEGG Compound 388529 ChemSpider 5901 ChemSpider 1.0 784 PubChem-compound Pantothenic acid (R)-pantoate pantothenate kinase C00055 KEGG Compound 7732-18-5 CAS 61-19-8 CAS SMILES NC1=C2N=CN([C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC=N1 C00063 KEGG Compound 63-68-3 CAS 5907 ChemSpider C10H16N5O13P3 Adenosine triphosphate 506.99576 HMDB0001256 HMDB HMDB0001377 HMDB HMDB0000045 HMDB HMDB0001016 HMDB 65-47-4 CAS HMDB0001257 HMDB S-adenosylmethionine decarboxylase C00073 KEGG Compound spermidine synthase C14H23N6O3S S-Adenosylmethioninamine 355.15524 ornithine decarboxylase Polyamine oxidase SMILES NCCC(O)=O HMDB0001373 HMDB 3-Aminopropanal 962 PubChem-compound 31983 ChemSpider 5800 ChemSpider C00077 KEGG Compound CO2 Carbon dioxide 43.98983 Hydrogen peroxide CMP BioCyc C00080 KEGG Compound HMDB0000056 HMDB SMILES O=O HMDB0002111 HMDB SMILES CC(C)(COP(O)(=O)OP(O)(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N)C(O)C(=O)NCCC(=O)NCCS 14265-44-2 CAS 6176 PubChem-compound 58-64-0 CAS S-adenosylmethionine synthetase Putrescine 963 ChemSpider 4'-phosphopantetheine S-adenosylmethionine decarboxylase P40506 UniProt 644102 PubChem-compound C3H7NO2S L-Cysteine 121.01975 4932 TAXONOMY 988 PubChem-compound 5941 ChemSpider 6083 PubChem-compound C00099 KEGG Compound C00097 KEGG Compound C03492 KEGG Compound 22833512 PubChem-compound 1.0 H2O Water 18.010565 H2O2 Hydrogen peroxide 34.005478 1.0 1.0 977 PubChem-compound HMDB0059597 HMDB SPERMIDINE BioCyc SMILES CC(C(=O)NCCC(=O)NCCS)C(C)(C)COP([O-])([O-])=O 1.0 SMILES CC(C)(CO)C(O)C([O-])=O 1.0 Q08438 UniProt C04352 KEGG Compound HMDB0000082 HMDB HMDB0001173 HMDB CHEBI:15905 ChEBI 7196-09-0 CAS 2457-80-9 CAS 17215925 ChemSpider 71-44-3 CAS SMILES N[C@@H](CS)C(O)=O phosphopantothenate-cysteine ligase Adenosine monophosphate 1.0 Q04430 UniProt SMILES O 13837702 ChemSpider SMILES OO C10H14N5O7P Adenosine monophosphate 347.06308 Q12074 UniProt C6H11O4 (R)-pantoate 147.06628 C12H23N2O6PS 4'-phosphopantetheine 354.10254 239 PubChem-compound HMDB0000538 HMDB 1.0 1.0 S-ADENOSYLMETHIONINAMINE BioCyc 128 ChemSpider 6816 PubChem-compound ADP BioCyc CHEBI:15729 ChEBI C3H7NO2 beta-Alanine 89.047676 6.3.2.5 false 6.3.2.5 Cytidine triphosphate + D-4'-Phosphopantothenate + L-Cysteine → 4'-Phosphopantothenoylcysteine + Cytidine monophosphate + Hydrogen Ion + Pyrophosphate LEFT_TO_RIGHT Reaction6291 false 4'-Phosphopantothenoylcysteine + Hydrogen Ion → 4'-phosphopantetheine + Carbon dioxide LEFT_TO_RIGHT 53-59-8 CAS 2.7.7.3 false 2.7.7.3 4'-phosphopantetheine + Adenosine triphosphate + Hydrogen Ion → Dephospho-CoA + Pyrophosphate LEFT_TO_RIGHT 2.7.1.24 false 2.7.1.24 Adenosine triphosphate + Dephospho-CoA → Adenosine diphosphate + Coenzyme A + Hydrogen Ion LEFT_TO_RIGHT 1038 PubChem-compound R-4-PHOSPHOPANTOTHENOYL-L-CYSTEINE BioCyc SMILES CSCC[C@H](N)C(O)=O GO:0005829 GENE ONTOLOGY 274 ChemSpider 2.5.1.6 false 2.5.1.6 Adenosine triphosphate + L-Methionine + Water → Phosphate + Pyrophosphate + S-Adenosylmethionine LEFT_TO_RIGHT 2.5.1.22 false 2.5.1.22 S-Adenosylmethioninamine + Spermidine → 5'-Methylthioadenosine + Hydrogen Ion + Spermine LEFT_TO_RIGHT 1.2.1.3 false 1.2.1.3 3-Aminopropanal + NADP + Water → Hydrogen Ion + NADPH + beta-Alanine LEFT_TO_RIGHT 6.3.2.1 false 6.3.2.1 (R)-pantoate + Adenosine triphosphate + beta-Alanine → Adenosine monophosphate + Hydrogen Ion + Pantothenic acid + Pyrophosphate LEFT_TO_RIGHT 1.0 Phosphopantothenoylcysteine decarboxylase subunit SIS2 2.7.1.33 false 2.7.1.33 Adenosine triphosphate + Pantothenic acid ? Adenosine diphosphate + D-4'-Phosphopantothenate + Hydrogen Ion 70-26-8 CAS 1.5.3.17 false 1.5.3.17 Oxygen + Spermine + Water → 3-Aminopropanal + Hydrogen peroxide + Spermidine LEFT_TO_RIGHT 4.1.1.17 false 4.1.1.17 Hydrogen Ion + Ornithine → Carbon dioxide + Putrescine LEFT_TO_RIGHT 2.5.1.16 false 2.5.1.16 Putrescine + S-Adenosylmethioninamine → 5'-Methylthioadenosine + Hydrogen Ion + Spermidine LEFT_TO_RIGHT Pyrophosphate 4.1.1.50 false 4.1.1.50 Hydrogen Ion + S-Adenosylmethionine → Carbon dioxide + S-Adenosylmethioninamine LEFT_TO_RIGHT C9H17NO5 Pantothenic acid 219.11067 O4P Phosphate 94.95342 485-80-3 CAS 6026 ChemSpider 5862 PubChem-compound 131 PubChem-compound P21182 UniProt Cytidine monophosphate HMDB0001414 HMDB C21H30N7O17P3 NADPH 745.0911 75 PubChem-compound C21H29N7O17P3 NADP 744.08325 S-Adenosylmethioninamine C5H12N2O2 Ornithine 132.08987 NADPH BioCyc CHEBI:16610 ChEBI Carbon dioxide CPD-6641 BioCyc HMDB0000574 HMDB HMDB0000210 HMDB HMDB0001423 HMDB HMDB0000696 HMDB 4-P-PANTOTHENATE BioCyc SMILES [O-]P([O-])([O-])=O SMILES CC(C)(CO)[C@@H](O)C(=O)NCCC(O)=O HMDB0000214 HMDB HMDB0000217 HMDB 124-38-9 CAS CHEBI:15414 ChEBI HMDB0001429 HMDB SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O HMDB0000221 HMDB SMILES NCCC[C@H](N)C(O)=O SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O beta-Alanine Metabolism CHEBI:15769 ChEBI 107-95-9 CAS 1.0 53-57-6 CAS 1.0 CHEBI:15625 ChEBI CHEBI:15746 ChEBI S-ADENOSYLMETHIONINE BioCyc SMILES O=C=O CHEBI:15980 ChEBI O7P2 Pyrophosphate 173.91193 234 ChemSpider 5957 PubChem-compound C9H16N3O14P3 Cytidine triphosphate 482.9845 439415 PubChem-compound dephospho-CoA kinase 22365-13-5 CAS spermidine synthase 1102 PubChem-compound 1103 PubChem-compound Adenosine triphosphate C10H15N5O10P2 Adenosine diphosphate 427.02942 CHEBI:16958 ChEBI CHEBI:61723 ChEBI C9H14N3O8P Cytidine monophosphate 323.05185 SMP0002307 SMPDB CPD-8587 BioCyc 3633-59-8 CAS 440304 PubChem-compound CHEBI:1146900 ChEBI SMILES NCCCCNCCCN SMILES NCCCNCCCCNCCCN 5-METHYLTHIOADENOSINE BioCyc 1.0 14000-31-8 CAS CO-A BioCyc 1072 ChemSpider 1071 ChemSpider 5675 ChemSpider B-ALANINE BioCyc S-Adenosylmethionine Ornithine C21H36N7O16P3S Coenzyme A 767.11523 Adenosine diphosphate SPERMINE BioCyc CHEBI:17509 ChEBI C4H12N2 Putrescine 88.10005 1.0 Spermine Synthase CHEBI:7916 ChEBI P54114 UniProt CHEBI:15422 ChEBI 6557 ChemSpider 1.0 1.0 Polyamine oxidase O2 Oxygen 31.98983 439335 PubChem-compound C21H35N7O13P2S Dephospho-CoA 687.14886 Water CHEBI:16643 ChEBI C00864 KEGG Compound CHEBI:16526 ChEBI 389278 ChemSpider CHEBI:16761 ChEBI 7782-44-7 CAS beta-Alanine 1.0 Q12455 UniProt 1.0 P08432 UniProt L-Methionine C00750 KEGG Compound pantetheine-phosphate adenylyltransferase 5'-Methylthioadenosine Phosphopantothenoylcysteine decarboxylase subunit VHS3 CHEBI:15377 ChEBI CHEBI:17677 ChEBI L-Cysteine CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] C11H15N5O3S 5'-Methylthioadenosine 297.08957 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 5886 PubChem-compound 1.0 1045 PubChem-compound C00882 KEGG Compound Phosphate Oxygen 280 PubChem-compound SMILES C[S+](CCCN)C[C@H]1O[C@H]([C@H](O)[C@@H]1O)N1C=NC2=C1N=CN=C2N 1.0 CHEBI:15468 ChEBI Cytidine triphosphate D-4'-Phosphopantothenate HMDB0000988 HMDB 1.0 P10659 UniProt 1.0 SMILES CC(C)(COP(O)(O)=O)[C@@H](O)C(=O)NCCC(=O)N[C@@H](CS)C(O)=O Spermidine 1061 PubChem-compound SMILES NCCC=O HMDB0001967 HMDB 24762165 PubChem-compound Aldehyde dehydrogenase [NAD(P)+] 2 P19358 UniProt 1.0 85-61-0 CAS L-ORNITHINE BioCyc