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spermidine synthase Spermine Synthase Aldehyde dehydrogenase [NAD(P)+] 2 pantoate β-alanine ligase pantothenate kinase phosphopantothenate- cysteine ligase pantetheine- phosphate adenylyltransferase dephospho-CoA kinase S- adenosylmethionine synthetase S- AdenosylMethionine requiring S- adenosylmethionine decarboxylase Polyamine oxidase Coenzyme A biosynthesis protein 3 Phosphopantothenoylcysteine decarboxylase subunit VHS3 Phosphopantothenoylcysteine decarboxylase subunit SIS2 ornithine decarboxylase Putrescine S- Adenosylmethioninamine H + 5'- Methylthioadenosine Spermidine S- Adenosylmethioninamine H + 5'- Methylthioadenosine Spermine 3-Aminopropanal H 2 O NADP β-Alanine H + NADPH (R)-pantoate ATP Pantothenic acid AMP PP i H + ATP D-4'- Phosphopantothenate ADP H + Cytidine triphosphate L-Cysteine Cytidine monophosphate PP i H + 4'- Phosphopantothenoylcysteine 4'- phosphopantetheine ATP H + PP i Dephospho-CoA ATP H + ADP Coenzyme A L-Methionine ATP H 2 O P i PP i S- Adenosylmethionine H + CO 2 H 2 O O 2 H 2 O 2 Spermidine H + CO 2 Ornithine H + CO 2
SPE3 SPE4 ALD3 PAN6 CAB1 CAB2 CAB4 CAB5 SAM1 SAM2 SPE2 FMS1 CAB3 VHS3 SIS2 SPE1 Putrescine S- Adenosylmethioninamine Hydrogen Ion 5'- Methylthioadenosine Spermidine S- Adenosylmethioninamine Hydrogen Ion 5'- Methylthioadenosine Spermine 3-Aminopropanal Water NADP β-Alanine Hydrogen Ion NADPH (R)-pantoate Adenosine triphosphate Pantothenic acid Adenosine monophosphate Pyrophosphate Hydrogen Ion Adenosine triphosphate D-4'- Phosphopantothenate Adenosine diphosphate Hydrogen Ion Cytidine triphosphate L-Cysteine Cytidine monophosphate Pyrophosphate Hydrogen Ion 4'- Phosphopantothenoylcysteine 4'- phosphopantetheine Adenosine triphosphate Hydrogen Ion Pyrophosphate Dephospho-CoA Adenosine triphosphate Hydrogen Ion Adenosine diphosphate Coenzyme A L-Methionine Adenosine triphosphate Water Phosphate Pyrophosphate S- Adenosylmethionine Hydrogen Ion Carbon dioxide Water Oxygen Hydrogen peroxide Spermidine Hydrogen Ion Carbon dioxide Ornithine Hydrogen Ion Carbon dioxide