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Pathway Description
4-Aminobutanoate Degradation
Saccharomyces cerevisiae
Metabolic Pathway
GABA(γ-aminobutyric acid) is a non-protein amino acid that can be accumulated via permease-mediated uptake by Uga4p, Put4p, and Gap1p. GABA can also be produced via glutamate degradation by the glutamate decarboxylase, this variant of the pathway includes a 2-oxoglutarate-dependent 4-aminobutyrate transaminase and an NAD+-dependent dehydrogenase. This combination of enzymes has been documented in bacteria and animals and in some plants. Regarding the hydrogenase, NAD-specific variants have been studied from many bacteria, plant and animals.
References
4-Aminobutanoate Degradation References
Coleman ST, Fang TK, Rovinsky SA, Turano FJ, Moye-Rowley WS: Expression of a glutamate decarboxylase homologue is required for normal oxidative stress tolerance in Saccharomyces cerevisiae. J Biol Chem. 2001 Jan 5;276(1):244-50. doi: 10.1074/jbc.M007103200.
Pubmed: 11031268
Idicula AM, Blatch GL, Cooper TG, Dorrington RA: Binding and activation by the zinc cluster transcription factors of Saccharomyces cerevisiae. Redefining the UASGABA and its interaction with Uga3p. J Biol Chem. 2002 Nov 29;277(48):45977-83. doi: 10.1074/jbc.M201789200. Epub 2002 Sep 13.
Pubmed: 12235130
Ramos F, el Guezzar M, Grenson M, Wiame JM: Mutations affecting the enzymes involved in the utilization of 4-aminobutyric acid as nitrogen source by the yeast Saccharomyces cerevisiae. Eur J Biochem. 1985 Jun 3;149(2):401-4.
Pubmed: 3888627
Vissers S, Andre B, Muyldermans F, Grenson M: Positive and negative regulatory elements control the expression of the UGA4 gene coding for the inducible 4-aminobutyric-acid-specific permease in Saccharomyces cerevisiae. Eur J Biochem. 1989 May 1;181(2):357-61.
Pubmed: 2653828
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