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S- adenosylmethionine synthetase S- AdenosylMethionine requiring S-adenosyl-L- homocysteine hydrolase aromatic amino acid aminotransferase II acireductone dioxygenase 2,3- dioxomethiopentane- 1-phosphate enolase/phosphatase Methylthioribulose- 1-phosphate DEhydratase MethylthioRibose- 1-phosphate Isomerase 5'- methylthioadenosine phosphorylase Aspartokinase aspartic beta semi-aldehyde dehydrogenase Homoserine dehydrogenase homoserine O-trans- acetylase Putative cystathionine beta-lyase N5- methyltetrahydropteroyltriglutamate- homocysteine methyltransferase L-Methionine ATP H2O Pi PPi S- Adenosylmethionine H+ S- Adenosylhomocysteine H2O Adenosine Homocysteine 2-Oxo-4- methylthiobutanoic acid L-Phenylalanine 2-Ketobutyric acid 1,2- Dihydroxy-3- keto-5- methylthiopentene O2 H+ Formic acid H2O 5- (Methylthio)- 2,3- dioxopentyl phosphate H+ Pi 5- Methylthioribulose 1-phosphate H2O 5- Methylthioribose 1-phosphate Pi 5'-S-methyl- 5'- thioadenosine Adenine L-Aspartic acid ATP ADP L-Aspartyl-4- phosphate NADPH H+ Pi NADP L-Aspartate- semialdehyde NADPH H+ L-Homoserine NADP Acetyl-CoA CoA Acetylhomoserine Hydrogen sulfide Acetic acid H+ 5- Methyltetrahydropteroyltri- L-glutamate Tetrahydropteroyltri- L-glutamate a demethylated methyl donor a methylated methyl donor Endocytosis