Loading Pathway...
CHEBI:16015 ChEBI 70-18-8 CAS 30572 ChemSpider 6022 PubChem-compound 1.0 OXIDIZED-GLUTATHIONE BioCyc 1.0 SMILES N[C@@H](CS)C(O)=O 52-90-4 CAS 937 ChemSpider CPD-8587 BioCyc CYS BioCyc 388596 ChemSpider C00037 KEGG Compound C8H14N2O5S gamma-Glutamylcysteine 250.06235 SMILES N[C@@H](CS)C(=O)NCC(O)=O Water 110467 ChemSpider Cysteinylglycine SMILES O 1.0 HMDB0001341 HMDB SMP0002317 SMPDB C01419 KEGG Compound CHEBI:17515 ChEBI HMDB0000538 HMDB ATP BioCyc L-Cysteine SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 1.0 HMDB0000148 HMDB C00051 KEGG Compound ADP BioCyc 1.0 glutathione synthetase Glutamate--cysteine ligase CHEBI:15422 ChEBI Q08220 UniProt 1.0 5742 ChemSpider 1038 PubChem-compound SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O 7732-18-5 CAS CHEBI:17561 ChEBI CYS-GLY BioCyc 123938 PubChem-compound 19246-18-5 CAS 56-86-0 CAS Cys-Gly metallodipeptidase Gamma-glutamyltransferase C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound gamma-Glutamylcysteine 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 Cys-Gly metallodipeptidase P32477 UniProt O4P Phosphate 94.95342 Glutamate--cysteine ligase 56-40-6 CAS glutathione synthetase Gamma-glutamyltransferase 5862 PubChem-compound CHEBI:16761 ChEBI 1010 ChemSpider Saccharomyces cerevisiae CHEBI:15428 ChEBI 962 PubChem-compound GLY BioCyc Hydrogen Ion 5800 ChemSpider CHEBI:16856 ChEBI 124886 PubChem-compound 636-58-8 CAS Phosphate 1.0 Adenosine triphosphate HMDB0000574 HMDB C00080 KEGG Compound L-Glutamic acid 730 ChemSpider SMILES [O-]P([O-])([O-])=O C2H5NO2 Glycine 75.03203 SMILES N[C@@H](CCC(O)=O)C(O)=O HMDB0002111 HMDB C00009 KEGG Compound CHEBI:15377 ChEBI C00008 KEGG Compound 14265-44-2 CAS CHEBI:15378 ChEBI SMILES [H+] 58-64-0 CAS HMDB0001429 HMDB C00001 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O PW002395 PathWhiz CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound 1.0 5257127 PubChem-compound C10H17N3O6S Glutathione 307.0838 Q05902 UniProt CHEBI:4047 ChEBI P43616 UniProt GLT BioCyc 111188 ChemSpider Glutathione C3H7NO2S L-Cysteine 121.01975 4932 TAXONOMY C00097 KEGG Compound HMDB0000078 HMDB 439498 PubChem-compound HMDB0001049 HMDB Glutathione Metabolism Glycine H2O Water 18.010565 5957 PubChem-compound SMILES NCC(O)=O C5H10N2O3S Cysteinylglycine 178.04121 C00669 KEGG Compound ReactionCatalysis6282 ACTIVATION 1061 PubChem-compound H Hydrogen Ion 1.007825 ReactionCatalysis6281 ACTIVATION ReactionCatalysis6280 ACTIVATION HMDB0059597 HMDB 1.0 ReactionCatalysis6283 ACTIVATION 56-65-5 CAS 5653 ChemSpider L-GAMMA-GLUTAMYLCYSTEINE BioCyc C00025 KEGG Compound HMDB0000123 HMDB Adenosine diphosphate HMDB0000125 HMDB C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O 6.3.2.2 false 6.3.2.2 Adenosine triphosphate + L-Cysteine + L-Glutamic acid → Adenosine diphosphate + Hydrogen Ion + Phosphate + gamma-Glutamylcysteine LEFT_TO_RIGHT 6.3.2.3 false 6.3.2.3 Adenosine triphosphate + Glycine + gamma-Glutamylcysteine → Adenosine diphosphate + Glutathione + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 2.3.2.2,3.4.19.13 false 2.3.2.2,3.4.19.13 Glutathione + L-Cysteine → Cysteinylglycine + gamma-Glutamylcysteine LEFT_TO_RIGHT 3.4.13.- false 3.4.13.- Cysteinylglycine + Water → Glycine + L-Cysteine LEFT_TO_RIGHT Glutamate-- cysteine ligase glutathione synthetase Gamma- glutamyltransferase Cys-Gly metallodipeptidase Glutamate-- cysteine ligase glutathione synthetase L-Glutamic acid L-Cysteine ATP ADP P i H + gamma- Glutamylcysteine Glycine ATP ADP P i H + Glutathione L-Cysteine Cysteinylglycine gamma- Glutamylcysteine H 2 O Glycine L-Cysteine L-Glutamic acid ATP ADP P i H + gamma- Glutamylcysteine Glycine ATP ADP P i H + Glutathione
CHEBI:16015 ChEBI 70-18-8 CAS 30572 ChemSpider 6022 PubChem-compound 1.0 OXIDIZED-GLUTATHIONE BioCyc 1.0 SMILES N[C@@H](CS)C(O)=O 52-90-4 CAS 937 ChemSpider CPD-8587 BioCyc CYS BioCyc 388596 ChemSpider C00037 KEGG Compound C8H14N2O5S gamma-Glutamylcysteine 250.06235 SMILES N[C@@H](CS)C(=O)NCC(O)=O Water 110467 ChemSpider Cysteinylglycine SMILES O 1.0 HMDB0001341 HMDB SMP0002317 SMPDB C01419 KEGG Compound CHEBI:17515 ChEBI HMDB0000538 HMDB ATP BioCyc L-Cysteine SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 1.0 HMDB0000148 HMDB C00051 KEGG Compound ADP BioCyc 1.0 glutathione synthetase Glutamate--cysteine ligase CHEBI:15422 ChEBI Q08220 UniProt 1.0 5742 ChemSpider 1038 PubChem-compound SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(O)=O)C(O)=O 7732-18-5 CAS CHEBI:17561 ChEBI CYS-GLY BioCyc 123938 PubChem-compound 19246-18-5 CAS 56-86-0 CAS Cys-Gly metallodipeptidase Gamma-glutamyltransferase C5H9NO4 L-Glutamic acid 147.05316 33032 PubChem-compound gamma-Glutamylcysteine 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 Cys-Gly metallodipeptidase P32477 UniProt O4P Phosphate 94.95342 Glutamate--cysteine ligase 56-40-6 CAS glutathione synthetase Gamma-glutamyltransferase 5862 PubChem-compound CHEBI:16761 ChEBI 1010 ChemSpider Saccharomyces cerevisiae CHEBI:15428 ChEBI 962 PubChem-compound GLY BioCyc Hydrogen Ion 5800 ChemSpider CHEBI:16856 ChEBI 124886 PubChem-compound 636-58-8 CAS Phosphate 1.0 Adenosine triphosphate HMDB0000574 HMDB C00080 KEGG Compound L-Glutamic acid 730 ChemSpider SMILES [O-]P([O-])([O-])=O C2H5NO2 Glycine 75.03203 SMILES N[C@@H](CCC(O)=O)C(O)=O HMDB0002111 HMDB C00009 KEGG Compound CHEBI:15377 ChEBI C00008 KEGG Compound 14265-44-2 CAS CHEBI:15378 ChEBI SMILES [H+] 58-64-0 CAS HMDB0001429 HMDB C00001 KEGG Compound SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O PW002395 PathWhiz CHEBI:18367 ChEBI 1032 ChemSpider C00002 KEGG Compound 1.0 5257127 PubChem-compound C10H17N3O6S Glutathione 307.0838 Q05902 UniProt CHEBI:4047 ChEBI P43616 UniProt GLT BioCyc 111188 ChemSpider Glutathione C3H7NO2S L-Cysteine 121.01975 4932 TAXONOMY C00097 KEGG Compound HMDB0000078 HMDB 439498 PubChem-compound HMDB0001049 HMDB Glutathione Metabolism Glycine H2O Water 18.010565 5957 PubChem-compound SMILES NCC(O)=O C5H10N2O3S Cysteinylglycine 178.04121 C00669 KEGG Compound ReactionCatalysis6282 ACTIVATION 1061 PubChem-compound H Hydrogen Ion 1.007825 ReactionCatalysis6281 ACTIVATION ReactionCatalysis6280 ACTIVATION HMDB0059597 HMDB 1.0 ReactionCatalysis6283 ACTIVATION 56-65-5 CAS 5653 ChemSpider L-GAMMA-GLUTAMYLCYSTEINE BioCyc C00025 KEGG Compound HMDB0000123 HMDB Adenosine diphosphate HMDB0000125 HMDB C10H15N5O10P2 Adenosine diphosphate 427.02942 SMILES N[C@@H](CCC(=O)N[C@@H](CS)C(=O)NCC(O)=O)C(O)=O 6.3.2.2 false 6.3.2.2 Adenosine triphosphate + L-Cysteine + L-Glutamic acid → Adenosine diphosphate + Hydrogen Ion + Phosphate + gamma-Glutamylcysteine LEFT_TO_RIGHT 6.3.2.3 false 6.3.2.3 Adenosine triphosphate + Glycine + gamma-Glutamylcysteine → Adenosine diphosphate + Glutathione + Hydrogen Ion + Phosphate LEFT_TO_RIGHT 2.3.2.2,3.4.19.13 false 2.3.2.2,3.4.19.13 Glutathione + L-Cysteine → Cysteinylglycine + gamma-Glutamylcysteine LEFT_TO_RIGHT 3.4.13.- false 3.4.13.- Cysteinylglycine + Water → Glycine + L-Cysteine LEFT_TO_RIGHT GSH1 GSH2 ECM38 DUG1 GSH1 GSH2 L-Glutamic acid L-Cysteine Adenosine triphosphate Adenosine diphosphate Phosphate Hydrogen Ion gamma- Glutamylcysteine Glycine Adenosine triphosphate Adenosine diphosphate Phosphate Hydrogen Ion Glutathione L-Cysteine Cysteinylglycine gamma- Glutamylcysteine Water Glycine L-Cysteine L-Glutamic acid Adenosine triphosphate Adenosine diphosphate Phosphate Hydrogen Ion gamma- Glutamylcysteine Glycine Adenosine triphosphate Adenosine diphosphate Phosphate Hydrogen Ion Glutathione