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Glutamate-- cysteine ligase glutathione synthetase Gamma- glutamyltransferase Cys-Gly metallodipeptidase Glutamate-- cysteine ligase glutathione synthetase L-Glutamic acid L-Cysteine ATP ADP P i H + γ- Glutamylcysteine Glycine ATP ADP P i H + Glutathione L-Cysteine Cysteinylglycine γ- Glutamylcysteine H 2 O Glycine L-Cysteine L-Glutamic acid ATP ADP P i H + γ- Glutamylcysteine Glycine ATP ADP P i H + Glutathione
GSH1 GSH2 ECM38 DUG1 GSH1 GSH2 L-Glutamic acid L-Cysteine Adenosine triphosphate Adenosine diphosphate Phosphate Hydrogen Ion γ- Glutamylcysteine Glycine Adenosine triphosphate Adenosine diphosphate Phosphate Hydrogen Ion Glutathione L-Cysteine Cysteinylglycine γ- Glutamylcysteine Water Glycine L-Cysteine L-Glutamic acid Adenosine triphosphate Adenosine diphosphate Phosphate Hydrogen Ion γ- Glutamylcysteine Glycine Adenosine triphosphate Adenosine diphosphate Phosphate Hydrogen Ion Glutathione