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3-ketoacyl-CoA synthase ELO1 Long-chain- fatty-acid-- CoA ligase 2 Very long-chain fatty acid transport protein long chain fatty acyl:CoA synthetase Long-chain- fatty-acid-- CoA ligase 1 Long-chain- fatty-acid-- CoA ligase 3 3-oxoacyl- [acyl- carrier- protein] reductase Peroxisomal hydratase- dehydrogenase- epimerase 2-enoyl thioester reductase Peroxisomal acyl-coenzyme A thioester hydrolase 1 Peroxisomal hydratase- dehydrogenase- epimerase 2-enoyl thioester reductase 3-ketoacyl-CoA synthase ELO1 3-oxoacyl- [acyl- carrier- protein] reductase Peroxisomal hydratase- dehydrogenase- epimerase 2-enoyl thioester reductase 3-ketoacyl-CoA synthase ELO1 3-ketoacyl-CoA synthase ELO1 3-oxoacyl- [acyl- carrier- protein] reductase 3-oxoacyl- [acyl- carrier- protein] reductase Peroxisomal hydratase- dehydrogenase- epimerase 2-enoyl thioester reductase 3-ketoacyl-CoA synthase ELO1 3-oxoacyl- [acyl- carrier- protein] reductase Peroxisomal hydratase- dehydrogenase- epimerase 2-enoyl thioester reductase dihydrosphingosine C-4 hydroxylase 3- ketosphinganine reductase Serine palmitoyltransferase 1 Ceramide synthase subunit LIP1 Palmityl-CoA Malonyl-CoA H + CO 2 3- Oxooctadecanoyl- CoA CoA Palmitic acid ATP CoA AMP PP i H + NADPH NADP (3R)-3- hydroxy- stearoyl-CoA trans- Octadec-2- enoyl-CoA H 2 O H + NADPH Stearoyl-CoA NADP H 2 O H + CoA Stearic acid (3R)-3- hydroxy- arachidoyl- CoA H 2 O (2E)- eicosenoyl- CoA H + NADPH Eicosanoyl-CoA NADP Malonyl-CoA H + CoA CO 2 3- oxodocosanoyl- CoA H + NADPH NADP (3R)-3- hydroxy- docosanoyl- CoA H 2 O trans-docos- 2-enoyl-CoA H + NADPH Docosanoyl-CoA NADP Malonyl-CoA H + CoA CO 2 3- oxotetracosanoyl- CoA H + Malonyl-CoA 3- oxoicosanoyl- CoA CoA CO 2 NADPH H + (3R)-3- hydroxy- arachidoyl- CoA NADP NADPH H + (3R)- hydroxytetracosanoyl- CoA NADP H 2 O (2E)- lignocerenoyl- CoA H + NADPH NADP Tetracosanoyl- CoA Malonyl-CoA H + CoA CO 2 3- oxohexacosanoyl- CoA H + NADPH NADP (3R)- hydroxyhexacosanoyl- CoA H 2 O (2E)- cerotenoyl- CoA H + NADPH Hexacosanoyl- CoA NADP H + O 2 Sphinganine H 2 O Phytosphingosine H + NADPH 3- Dehydrosphinganine NADP Palmityl-CoA L-Serine H + CoA CO 2 Hexacosanoyl- CoA Hydrogen ion CoA N- hexacosanoyl- C20-4- hydroxysphinganine ferrocytochrome b5 ferricytochrome b5