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Ribose- phosphate pyrophosphokinase 1 Ribose- phosphate pyrophosphokinase 2 Ribose- phosphate pyrophosphokinase 3 Ribose- phosphate pyrophosphokinase 4 Ribose- phosphate pyrophosphokinase 5 histidine biosynthesis trifunctional protein ATP phosphoribosyltransferase histidine biosynthesis trifunctional protein 1-(5- phosphoribosyl)- 5-[(5- phosphoribosylamino)methylideneamino] imidazole-4- carboxamide isomerase Imidazole glycerol phosphate synthase hisHF Imidazoleglycerol- phosphate dehydratase histidinol- phosphate aminotransferase Histidinol- phosphatase histidine biosynthesis trifunctional protein histidine biosynthesis trifunctional protein D-Ribose 5-phosphate ATP AMP H + Phosphoribosyl pyrophosphate Phosphoribosyl- AMP H 2 O PhosphoribosylformiminoAICAR- phosphate ATP H + PP i 1-(5- phosphoribosyl)- ATP H 2 O Phosphoribosyl- AMP H + PP i Phosphoribulosylformimino- AICAR-P L-Glutamine L-Glutamic acid H + AICAR D-Erythro- imidazole- glycerol- phosphate H 2 O Imidazole acetol- phosphate L-Glutamic acid Oxoglutaric acid L-histidinol phosphate H 2 O L-Histidinol P i NAD H + NADH Histidinal H 2 O NAD H + NADH L-Histidine
PRS1 PRS2 PRS3 PRS4 PRS5 HIS4 HIS1 HIS4 HIS6 HIS7 HIS3 HIS5 HIS2 HIS4 HIS4 D-Ribose 5-phosphate Adenosine triphosphate Adenosine monophosphate Hydrogen Ion Phosphoribosyl pyrophosphate Phosphoribosyl- AMP Water PhosphoribosylformiminoAICAR- phosphate Adenosine triphosphate Hydrogen Ion Pyrophosphate 1-(5- phosphoribosyl)- ATP Water Phosphoribosyl- AMP Hydrogen Ion Pyrophosphate Phosphoribulosylformimino- AICAR-P L-Glutamine L-Glutamic acid Hydrogen Ion AICAR D-Erythro- imidazole- glycerol- phosphate Water Imidazole acetol- phosphate L-Glutamic acid Oxoglutaric acid L-histidinol phosphate Water L-Histidinol Phosphate NAD Hydrogen Ion NADH Histidinal Water NAD Hydrogen Ion NADH L-Histidine