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Pathway Description
Glyoxylate Cycle
Saccharomyces cerevisiae
Metabolic Pathway
The glyoxylate cycle begins with glyoxylic acid reacting with acetyl-coa through a malate synthase resulting in the release of a L-malic acid. The L-malic acid reacts with an NAD dependent malate dehydrogenase resulting in the release of a oxalacetic acid. This compound in turn reacts with an acetyl-coa through a citrate synthase resulting in the release of citric acid reacts with aconitate hydratase resulting in the release of water molecule and a cis-aconitate. This compound in turn react with a water molecule to produce D-threo-isocitric acid. The resulting compoun then reacts with an isocitrate lyase resulting in the release of a succinic acid and a glyoxylic acid.
References
Glyoxylate Cycle References
Duntze W, Neumann D, Gancedo JM, Atzpodien W, Holzer H: Studies on the regulation and localization of the glyoxylate cycle enzymes in Saccharomyces cerevisiae. Eur J Biochem. 1969 Aug;10(1):83-9.
Pubmed: 5345986
Regev-Rudzki N, Karniely S, Ben-Haim NN, Pines O: Yeast aconitase in two locations and two metabolic pathways: seeing small amounts is believing. Mol Biol Cell. 2005 Sep;16(9):4163-71. doi: 10.1091/mbc.e04-11-1028. Epub 2005 Jun 22.
Pubmed: 15975908
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