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Mitochondria Homocitrate synthase, mitochondrial Homocitrate synthase, cytosolic isozyme Homoaconitase, mitochondrial Homoisocitrate dehydrogenase, mitochondrial L-2- aminoadipate reductase L-2- aminoadipate reductase Saccharopine dehydrogenase [NADP(+), L-glutamate- forming] Saccharopine dehydrogenase [NAD(+), L-lysine- forming] Oxoglutaric acid Acetyl-CoA H 2 O CoA Homocitric acid H + Oxoglutaric acid Acetyl-CoA H 2 O Homocitric acid CoA H + H 2 O cis- homoaconitate H 2 O cis- homoaconitate H 2 O (1R,2S)- homoisocitrate NAD CO 2 NADH Oxoadipic acid L-Glutamic acid Oxoglutaric acid Aminoadipic acid ATP PP i AMP H + NADPH NADP Allysine NADPH L-Glutamic acid H + H 2 O NADP Saccharopine NAD H 2 O NADH H + Oxoglutaric acid L-Lysine holo-[LYS2 peptidyl- carrier- protein] L-2- aminoadipyl- [LYS2 peptidyl- carrier- protein] holo-[LYS2 peptidyl- carrier- protein]
Mitochondria LYS21 LYS20 LYS4 LYS12 LYS2 LYS2 LYS9 LYS1 Oxoglutaric acid Acetyl-CoA Water Coenzyme A Homocitric acid Hydrogen Ion Oxoglutaric acid Acetyl-CoA Water Homocitric acid Coenzyme A Hydrogen Ion Water cis- homoaconitate Water cis- homoaconitate Water (1R,2S)- homoisocitrate NAD Carbon dioxide NADH Oxoadipic acid L-Glutamic acid Oxoglutaric acid Aminoadipic acid Adenosine triphosphate Pyrophosphate Adenosine monophosphate Hydrogen Ion NADPH NADP Allysine NADPH L-Glutamic acid Hydrogen Ion Water NADP Saccharopine NAD Water NADH Hydrogen Ion Oxoglutaric acid L-Lysine holo-[LYS2 peptidyl- carrier- protein] L-2- aminoadipyl- [LYS2 peptidyl- carrier- protein] holo-[LYS2 peptidyl- carrier- protein]