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5- aminolevulinate synthase, nonspecific, mitochondrial Delta- aminolevulinic acid dehydratase Porphobilinogen deaminase Uroporphyrinogen- III synthase Uroporphyrinogen decarboxylase Uroporphyrinogen decarboxylase Coproporphyrinogen- III oxidase, mitochondrial Protoporphyrinogen oxidase Ferritin, mitochondrial Ferrochelatase, mitochondrial Protoheme IX farnesyltransferase, mitochondrial Cytochrome c oxidase assembly protein COX15 homolog Heme oxygenase 1 Biliverdin reductase A UDP- glucuronosyltransferase 2B11 Beta- glucuronidase Glycine Coproporphyrinogen III Coproporphyrinogen III Protoporphyrin IX Heme Succinyl-CoA 5- Aminolevulinic acid CO 2 Porphobilinogen H 2 O H 2 O Hydroxymethylbilane NH 3 Uroporphyrinogen III H 2 O Uroporphyrin III Uroporphyrinogen I Coproporphyrinogen I CO 2 Coproporphyrin I Uroporphyrin I CO 2 Coproporphyrin III O 2 H + Protoporphyrinogen IX CO 2 H 2 O O 2 Protoporphyrin IX H 2 O 2 Fe2+ H + O 2 Fe3+ H 2 O Heme H + Farnesyl pyrophosphate Heme O Heme A O 2 Biliverdin Fe2+ Carbon monoxide H 2 O NAD Bilirubin NADH Uridine diphosphate glucuronic acid Bilirubin diglucuronide Uridine 5'-diphosphate H 2 O D-Urobilinogen Pyridoxal 5'-phosphate Zinc FAD 2Fe-2S Zinc AH2 A Alcohol Glycine and Serine Metabolism Intracellular Space Mitochondria Outer mitochondrial membrane Inner mitochondrial membrane Microsome Microsome Lysosome