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methionine-- tRNA ligase MSM1 methionine-- tRNA ligase MES1 cystathionine gamma-lyase N5- methyltetrahydropteroyltriglutamate- homocysteine methyltransferase cystathionine beta-lyase cystathionine beta-lyase subunit 2 cystathionine gamma-synthase cystathionine gamma-synthase thioredoxin reductase 1 thioredoxin reductase 2 cystathionine gamma-lyase ATP Selenomethionine AMP PP i H 2 O methylselenol NH 3 2-Ketobutyric acid Selenohomocysteine 5- Methyltetrahydropteroyltri- L-glutamate Tetrahydropteroyltri- L-glutamate Selenocystathionine H 2 O NH 3 Pyruvic acid O-succinyl-L- homoserine Selenocysteine Succinic acid Selenocysteine Acetylhomoserine Acetic acid NADPH H + Methylselenic acid NADP H 2 O Se- Methylselenocysteine H 2 O NH 3 Pyruvic acid Selenomethionyl- tRNA(Met) tRNA(Met)
MSM1 MES1 CYS3 MET6 IRC7 STR3 STR2 STR2 TRR1 TRR2 CYS3 Adenosine triphosphate Selenomethionine Adenosine monophosphate Pyrophosphate Water methylselenol Ammonia 2-Ketobutyric acid Selenohomocysteine 5- Methyltetrahydropteroyltri- L-glutamate Tetrahydropteroyltri- L-glutamate Selenocystathionine Water Ammonia Pyruvic acid O-succinyl-L- homoserine Selenocysteine Succinic acid Selenocysteine Acetylhomoserine Acetic acid NADPH Hydrogen Ion Methylselenic acid NADP Water Se- Methylselenocysteine Water Ammonia Pyruvic acid Selenomethionyl- tRNA(Met) tRNA(Met)