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CHEBI:16136 ChEBI 454-29-5 CAS 6022 PubChem-compound Hydrogen sulfide P53206 UniProt 937 ChemSpider PW002483 PathWhiz CYS BioCyc 123991 PubChem-compound S2O3 BioCyc 4.0 1.0 18779926 PubChem-compound 57 ChemSpider 50 ChemSpider Acetylhomoserine 1.0 HMDB0000099 HMDB CHEBI:17359 ChEBI CHEBI:17115 ChEBI P06106 UniProt 2-Aminoacrylic acid C00320 KEGG Compound Reaction6939 false Thiosulfate → Sulfate LEFT_TO_RIGHT CHEBI:17230 ChEBI ATP BioCyc H4N Ammonium 18.034374 3.1.3.7 false 3.1.3.7 Phosphoadenosine phosphosulfate + Water ↔ Adenosine phosphosulfate + Phosphate REVERSIBLE 3.0 1.8.4.8 false 1.8.4.8 Phosphoadenosine phosphosulfate + reduced thioredoxin → Adenosine 3',5'-diphosphate + Hydrogen Ion + Sulfite + oxidized thioredoxin LEFT_TO_RIGHT 1.14.11.17 false 1.14.11.17 Oxoglutaric acid + Oxygen + Taurine → Aminoacetaldehyde + Carbon dioxide + Hydrogen Ion + Succinic acid + Sulfite LEFT_TO_RIGHT ReactionCatalysis6229 ACTIVATION 2.8.1.1 false 2.8.1.1 Cyanide + Thiosulfate → Hydrogen Ion + Sulfite + Thiocyanate LEFT_TO_RIGHT 14808-79-8 CAS 1.8.1.2 false 1.8.1.2 5 Hydrogen Ion + 3 NADPH + Sulfite → Hydrogen sulfide + NADP + 3 Water LEFT_TO_RIGHT 2.5.1.47 false 2.5.1.47 Hydrogen sulfide + O-Acetylserine ↔ Acetic acid + Hydrogen Ion + L-Cysteine REVERSIBLE 559142 ChemSpider Reaction6938 false L-Cysteine → 2-Aminoacrylic acid + Hydrogen Ion + Hydrogen sulfide LEFT_TO_RIGHT Unknown ReactionCatalysis6228 ACTIVATION HMDB0003011 HMDB ReactionCatalysis6226 ACTIVATION 2.7.1.25 false 2.7.1.25 Adenosine phosphosulfate + Adenosine triphosphate → Adenosine diphosphate + Hydrogen Ion + Phosphoadenosine phosphosulfate LEFT_TO_RIGHT 1.0 5742 ChemSpider CHEBI:17561 ChEBI CHEBI:16474 ChEBI 952 ChemSpider 1.0 L-CYSTATHIONINE BioCyc 1.0 5736 ChemSpider C00109 KEGG Compound C00224 KEGG Compound 1010 ChemSpider CHEBI:15033 ChEBI Saccharomyces cerevisiae PPI BioCyc HMDB0003276 HMDB Ammonium Hydrogen Ion 2.0 Adenosine triphosphate SUC BioCyc C6H11NO4 Acetylhomoserine 161.0688 P05453 UniProt C00009 KEGG Compound C00008 KEGG Compound C00007 KEGG Compound C00006 KEGG Compound 5755 ChemSpider CHEBI:18009 ChEBI Phosphoadenosine phosphosulfate C00001 KEGG Compound P18408 UniProt CHEBI:18361 ChEBI C00005 KEGG Compound CHEBI:18367 ChEBI 2.0 CHEBI:16189 ChEBI 1032 ChemSpider C00245 KEGG Compound 2-OXOBUTANOATE BioCyc C00002 KEGG Compound 1031 ChemSpider APS BioCyc 1.0 1.0 O-acetylhomoserine (thiol)-lyase cystathionine beta-synthase HMDB0002084 HMDB HMDB0029423 HMDB 1.0 cystathionine gamma-lyase C3H5NO2 2-Aminoacrylic acid 87.03203 1068 ChemSpider CHEBI:17482 ChEBI C00011 KEGG Compound C01342 KEGG Compound 1.0 CHEBI:17123 ChEBI C00013 KEGG Compound NAD(P) BioCyc H2S Hydrogen sulfide 33.98772 H Hydrogen Ion 1.007825 1.0 1.0 C00022 KEGG Compound 56-65-5 CAS 5653 ChemSpider 56-88-2 CAS C00026 KEGG Compound 1054 ChemSpider ACET BioCyc 482-67-7 CAS 1.0 C02218 KEGG Compound CHEBI:16094 ChEBI 52-90-4 CAS C00033 KEGG Compound C5H9NO4 O-Acetylserine 147.05316 P47169 UniProt 328-50-7 CAS SMILES [O-]S([S-])(=O)=O HMDB0000254 HMDB Water SMILES OC(=O)CCC(O)=O HMDB0000257 HMDB C00283 KEGG Compound C10H14N5O10PS Adenosine phosphosulfate 427.0199 528 PubChem-compound HMDB0000251 HMDB 4.4.1.1 false 4.4.1.1 L-Cystathionine + Water → 2-Ketobutyric acid + Ammonium + L-Cysteine LEFT_TO_RIGHT HMDB0000250 HMDB SMILES NCCS(O)(=O)=O SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB 10238 PubChem-compound C00042 KEGG Compound L-Cysteine 2.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 SMILES C#[N-] SMILES N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O Putative cysteine synthase SO3 BioCyc Putative cysteine synthase Uncharacterized trans-sulfuration enzyme YHR112C NADPH-dependent diflavin oxidoreductase 1 C10H15N5O13P2S Phosphoadenosine phosphosulfate 506.98624 Thiosulfate sulfurtransferase TUM1 140102 ChemSpider C00177 KEGG Compound SMILES [O-]S([O-])(=O)=O SMILES CC(O)=O C00054 KEGG Compound C00053 KEGG Compound 7732-18-5 CAS 1.0 C00059 KEGG Compound HMDB0001003 HMDB SMILES [S-]C#N 2-iminopropanoate Adenosine phosphosulfate Sulfite reductase [NADPH] subunit beta cytochrome c isoform 2 cytochrome c isoform 1 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:18022 ChEBI C00065 KEGG Compound 1.0 10214 PubChem-compound O-Acetylserine 485-84-7 CAS HMDB0001377 HMDB HMDB0001134 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O SMILES CC(=O)C(O)=O SMILES [O-]S([O-])=O Phosphoadenosine phosphosulfate reductase Alpha-ketoglutarate-dependent sulfonate dioxygenase HMDB0000042 HMDB Eukaryotic peptide chain release factor GTP-binding subunit Adenylyl-sulfate kinase 962 PubChem-compound 5800 ChemSpider Q08686 UniProt Unknown CO2 Carbon dioxide 43.98983 Phosphate C00080 KEGG Compound CHEBI:77456 ChEBI SMILES O=O Oxoglutaric acid 7540-67-2 CAS 1.0 HMDB0002111 HMDB C4H9NO2S Homocysteine 135.0354 1.0 14265-44-2 CAS PYRUVATE BioCyc P00044 UniProt P00045 UniProt 58-64-0 CAS 2-Ketobutyric acid CHEBI:7671 ChEBI 9322 PubChem-compound HOMO-CYS BioCyc C00094 KEGG Compound L-Serine C4H6O3 2-Ketobutyric acid 102.03169 Sulfur Metabolism ACETYLSERINE BioCyc HMDB0000061 HMDB C3H7NO3 L-Serine 105.042595 HMDB0000187 HMDB 644102 PubChem-compound C3H7NO2S L-Cysteine 121.01975 4932 TAXONOMY SMILES NCC=O C00097 KEGG Compound 757 ChemSpider 1.0 513 ChemSpider 22833512 PubChem-compound Homocysteine H2O Water 18.010565 57-12-5 CAS 14265-45-3 CAS 977 PubChem-compound HMDB0059597 HMDB HMDB0041827 HMDB Carbon dioxide 110510 ChemSpider C02291 KEGG Compound cystathionine beta-synthase 17215925 ChemSpider C2H4O2 Acetic acid 60.02113 Reaction2902 true 2-Aminoacrylic acid → 2-iminopropanoate LEFT_TO_RIGHT Reaction2903 true 2-iminopropanoate + Hydrogen Ion + Water → Ammonium + Pyruvic acid LEFT_TO_RIGHT O-acetylhomoserine (thiol)-lyase SMILES N[C@@H](CS)C(O)=O Q12181 UniProt O4S Sulfate 95.95173 5975 PubChem-compound C2H5NO Aminoacetaldehyde 59.037113 Succinic acid C05330 KEGG Compound SMP0002382 SMPDB 4.0 Taurine CNS Thiocyanate 57.975143 64-19-7 CAS Thiosulfate SMILES O Pyrophosphate 5147-00-2 CAS P38716 UniProt HMDB0000538 HMDB 1123 PubChem-compound ReactionCatalysis6903 ACTIVATION ReactionCatalysis6902 ACTIVATION Sulfite ReactionCatalysis6901 ACTIVATION 1.0 ReactionCatalysis6907 ACTIVATION 51 PubChem-compound 89874 ChemSpider ReactionCatalysis6905 ACTIVATION ReactionCatalysis6904 ACTIVATION Adenosine 3',5'-diphosphate Pyruvic acid ADP BioCyc C10H15N5O10P2 Adenosine 3',5'-diphosphate 427.02942 C3H4O3 Pyruvic acid 88.016045 58 PubChem-compound O3S Sulfite 79.95682 49791978 PubChem-compound 1.0 1.0 53-59-8 CAS SMILES CC(=O)OC[C@H](N)C(O)=O ReactionCatalysis6909 ACTIVATION 1038 PubChem-compound ReactionCatalysis6908 ACTIVATION SMILES CC(=N)C([O-])=O Phosphoadenosine phosphosulfate reductase ReactionCatalysis6914 ACTIVATION Adenylyl-sulfate kinase Thiocyanate ReactionCatalysis6913 ACTIVATION ReactionCatalysis6912 ACTIVATION Alpha-ketoglutarate-dependent sulfonate dioxygenase ReactionCatalysis6911 ACTIVATION Eukaryotic peptide chain release factor GTP-binding subunit ReactionCatalysis6916 ACTIVATION SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](O)[C@H]1O 274 ChemSpider ReactionCatalysis6915 ACTIVATION C5H6O5 Oxoglutaric acid 146.02153 391 ChemSpider ReactionCatalysis6910 ACTIVATION 1.0 Sulfate O4P Phosphate 94.95342 NADPH 5862 PubChem-compound SER BioCyc Acetic acid 1948-56-7 CAS Sulfite reductase [NADPH] subunit beta NADPH-dependent diflavin oxidoreductase 1 NADP cytochrome c isoform 1 600-18-0 CAS cytochrome c isoform 2 C21H30N7O17P3 NADPH 745.0911 Putative cysteine synthase 3-5-ADP BioCyc Thiosulfate sulfurtransferase TUM1 302-04-5 CAS Uncharacterized trans-sulfuration enzyme YHR112C C21H29N7O17P3 NADP 744.08325 Putative cysteine synthase oxidized thioredoxin NADPH BioCyc reduced thioredoxin 1053-73-2 CAS HMDB0000208 HMDB CPD-6641 BioCyc 218 ChemSpider C3H4NO2 2-iminopropanoate 86.02475 HMDB0000574 HMDB SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O HMDB0000217 HMDB Oxygen CHEBI:30915 ChEBI 124-38-9 CAS 4.0 HSCN BioCyc HMDB0001429 HMDB HMDB0003609 HMDB 9799 ChemSpider CHEBI:15891 ChEBI SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 1.0 HMDB0000221 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 6971051 PubChem-compound 159296 PubChem-compound 2.5.1.49,2.5.1.47 false 2.5.1.49,2.5.1.47 Acetylhomoserine + Hydrogen sulfide → Acetic acid + Homocysteine + Hydrogen Ion LEFT_TO_RIGHT 7783-06-4 CAS 4.2.1.22 false 4.2.1.22 Homocysteine + L-Serine → L-Cystathionine + Water LEFT_TO_RIGHT 2.0 CHEBI:17709 ChEBI 1.0 53-57-6 CAS CHEBI:15741 ChEBI SMILES O=C=O CHEBI:28938 ChEBI 5951 PubChem-compound 1110 PubChem-compound C2H7NO3S Taurine 125.01466 O7P2 Pyrophosphate 173.91193 1117 PubChem-compound 1.0 5957 PubChem-compound HMDB0001448 HMDB Q02196 UniProt O3S2 Thiosulfate 111.92889 SMILES NC(CCS)C(O)=O C4H6O4 Succinic acid 118.02661 Aminoacetaldehyde reduced thioredoxin Adenosine diphosphate HMDB0001453 HMDB HMDB0000243 HMDB SMILES N[C@@H](CO)C(O)=O Cyanide C10H15N5O10P2 Adenosine diphosphate 427.02942 L-Cystathionine HMDB0000005 HMDB SMILES CCC(=O)C(O)=O CHN Cyanide 27.010899 C7H14N2O4S L-Cystathionine 222.06743 HMDB0000240 HMDB CHEBI:17985 ChEBI SMILES NC(=C)C(O)=O 3.0 1085 ChemSpider CPD-8587 BioCyc CHEBI:17981 ChEBI 1099 PubChem-compound CHEBI:17980 ChEBI CHEBI:30831 ChEBI oxidized thioredoxin 5.0 1091 ChemSpider P32582 UniProt P31373 UniProt 14000-31-8 CAS 1084 PubChem-compound CHEBI:17514 ChEBI 5675 ChemSpider 1078 ChemSpider SMILES S 14798-03-9 CAS CHEBI:17628 ChEBI Q12358 UniProt NH42SO4 BioCyc CHEBI:15422 ChEBI C00979 KEGG Compound 9821 ChemSpider O2 Oxygen 31.98983 1.0 127-17-3 CAS 1.0 SMILES [NH4+] 107-35-7 CAS CHEBI:16526 ChEBI 1.0 8961 ChemSpider CHEBI:16761 ChEBI 7782-44-7 CAS 1.0 CHEBI:15366 ChEBI 2-KETOGLUTARATE BioCyc sulfate adenylyltransferase 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](OP(O)(O)=O)[C@H]1O 388392 ChemSpider 8.0 1.0 PAPS BioCyc 2.0 110-15-6 CAS 171 ChemSpider CHEBI:32816 ChEBI CHEBI:15377 ChEBI CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] tryptophanase / L-cysteine desulfhydrase SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon 56-45-1 CAS 5886 PubChem-compound O-acetylserine sulfhydrylase A cysteine synthase B thiosulfate sulfurtransferase sulfite reductase 1.0 1.0 3'-phospho-adenylylsulfate reductase 280 PubChem-compound HMDB0000742 HMDB adenylylsulfate kinase 16741146 PubChem-compound 25243997 PubChem-compound 2.7.7.4 false 2.7.7.4 Adenosine triphosphate + Hydrogen Ion + Sulfate → Adenosine phosphosulfate + Pyrophosphate LEFT_TO_RIGHT 1.0 cytochrome c HS BioCyc cystathionine-β-lyase / L-cysteine desulfhydrase SMILES CC(=O)OCCC(N)C(O)=O 1060 PubChem-compound 1061 PubChem-compound C01755 KEGG Compound 4.0 cystathionine gamma-lyase HMDB0001967 HMDB 14383-50-7 CAS 176 PubChem-compound 1.0 Unknown Unknown Eukaryotic peptide chain release factor GTP-binding subunit Adenylyl- sulfate kinase phosphoadenylate 3'-nucleotidase Phosphoadenosine phosphosulfate reductase Alpha- ketoglutarate- dependent sulfonate dioxygenase thiosulfate sulfurtransferase thiosulfate sulfurtransferase Thiosulfate sulfurtransferase TUM1 thiosulfate sulfurtransferase Sulfite reductase [NADPH] subunit beta Unknown Uncharacterized trans- sulfuration enzyme YHR112C Putative cysteine synthase Putative cysteine synthase cytochrome c isoform 2 cytochrome c isoform 1 O- acetylhomoserine (thiol)-lyase cystathionine beta-synthase cystathionine gamma-lyase ATP H + Sulfate Adenosine phosphosulfate PP i ATP Phosphoadenosine phosphosulfate ADP H + H 2 O P i Adenosine phosphosulfate Sulfite H + Adenosine 3',5'- diphosphate Taurine Oxoglutaric acid O 2 Sulfite Succinic acid CO 2 H + Aminoacetaldehyde Cyanide Thiosulfate Thiocyanate Sulfite H + NADPH H + H 2 O NADP Hydrogen sulfide O-Acetylserine L-Cysteine Acetic acid H + H + Hydrogen sulfide 2-Aminoacrylic acid 2- iminopropanoate H 2 O H + Ammonium Pyruvic acid Sulfate Acetylhomoserine Acetic acid H + Homocysteine L-Serine H 2 O L-Cystathionine H 2 O Ammonium L-Cysteine 2-Ketobutyric acid Magnesium Siroheme Pyridoxal 5'-phosphate reduced thioredoxin oxidized thioredoxin NADPH-dependent diflavin oxidoreductase 1 Putative cysteine synthase Putative cysteine synthase 4Fe-4S FAD Flavin Mononucleotide Pyridoxal 5'-phosphate
CHEBI:16136 ChEBI 454-29-5 CAS 6022 PubChem-compound Hydrogen sulfide P53206 UniProt 937 ChemSpider PW002483 PathWhiz CYS BioCyc 123991 PubChem-compound S2O3 BioCyc 4.0 1.0 18779926 PubChem-compound 57 ChemSpider 50 ChemSpider Acetylhomoserine 1.0 HMDB0000099 HMDB CHEBI:17359 ChEBI CHEBI:17115 ChEBI P06106 UniProt 2-Aminoacrylic acid C00320 KEGG Compound Reaction6939 false Thiosulfate → Sulfate LEFT_TO_RIGHT CHEBI:17230 ChEBI ATP BioCyc H4N Ammonium 18.034374 3.1.3.7 false 3.1.3.7 Phosphoadenosine phosphosulfate + Water ↔ Adenosine phosphosulfate + Phosphate REVERSIBLE 3.0 1.8.4.8 false 1.8.4.8 Phosphoadenosine phosphosulfate + reduced thioredoxin → Adenosine 3',5'-diphosphate + Hydrogen Ion + Sulfite + oxidized thioredoxin LEFT_TO_RIGHT 1.14.11.17 false 1.14.11.17 Oxoglutaric acid + Oxygen + Taurine → Aminoacetaldehyde + Carbon dioxide + Hydrogen Ion + Succinic acid + Sulfite LEFT_TO_RIGHT ReactionCatalysis6229 ACTIVATION 2.8.1.1 false 2.8.1.1 Cyanide + Thiosulfate → Hydrogen Ion + Sulfite + Thiocyanate LEFT_TO_RIGHT 14808-79-8 CAS 1.8.1.2 false 1.8.1.2 5 Hydrogen Ion + 3 NADPH + Sulfite → Hydrogen sulfide + NADP + 3 Water LEFT_TO_RIGHT 2.5.1.47 false 2.5.1.47 Hydrogen sulfide + O-Acetylserine ↔ Acetic acid + Hydrogen Ion + L-Cysteine REVERSIBLE 559142 ChemSpider Reaction6938 false L-Cysteine → 2-Aminoacrylic acid + Hydrogen Ion + Hydrogen sulfide LEFT_TO_RIGHT Unknown ReactionCatalysis6228 ACTIVATION HMDB0003011 HMDB ReactionCatalysis6226 ACTIVATION 2.7.1.25 false 2.7.1.25 Adenosine phosphosulfate + Adenosine triphosphate → Adenosine diphosphate + Hydrogen Ion + Phosphoadenosine phosphosulfate LEFT_TO_RIGHT 1.0 5742 ChemSpider CHEBI:17561 ChEBI CHEBI:16474 ChEBI 952 ChemSpider 1.0 L-CYSTATHIONINE BioCyc 1.0 5736 ChemSpider C00109 KEGG Compound C00224 KEGG Compound 1010 ChemSpider CHEBI:15033 ChEBI Saccharomyces cerevisiae PPI BioCyc HMDB0003276 HMDB Ammonium Hydrogen Ion 2.0 Adenosine triphosphate SUC BioCyc C6H11NO4 Acetylhomoserine 161.0688 P05453 UniProt C00009 KEGG Compound C00008 KEGG Compound C00007 KEGG Compound C00006 KEGG Compound 5755 ChemSpider CHEBI:18009 ChEBI Phosphoadenosine phosphosulfate C00001 KEGG Compound P18408 UniProt CHEBI:18361 ChEBI C00005 KEGG Compound CHEBI:18367 ChEBI 2.0 CHEBI:16189 ChEBI 1032 ChemSpider C00245 KEGG Compound 2-OXOBUTANOATE BioCyc C00002 KEGG Compound 1031 ChemSpider APS BioCyc 1.0 1.0 O-acetylhomoserine (thiol)-lyase cystathionine beta-synthase HMDB0002084 HMDB HMDB0029423 HMDB 1.0 cystathionine gamma-lyase C3H5NO2 2-Aminoacrylic acid 87.03203 1068 ChemSpider CHEBI:17482 ChEBI C00011 KEGG Compound C01342 KEGG Compound 1.0 CHEBI:17123 ChEBI C00013 KEGG Compound NAD(P) BioCyc H2S Hydrogen sulfide 33.98772 H Hydrogen Ion 1.007825 1.0 1.0 C00022 KEGG Compound 56-65-5 CAS 5653 ChemSpider 56-88-2 CAS C00026 KEGG Compound 1054 ChemSpider ACET BioCyc 482-67-7 CAS 1.0 C02218 KEGG Compound CHEBI:16094 ChEBI 52-90-4 CAS C00033 KEGG Compound C5H9NO4 O-Acetylserine 147.05316 P47169 UniProt 328-50-7 CAS SMILES [O-]S([S-])(=O)=O HMDB0000254 HMDB Water SMILES OC(=O)CCC(O)=O HMDB0000257 HMDB C00283 KEGG Compound C10H14N5O10PS Adenosine phosphosulfate 427.0199 528 PubChem-compound HMDB0000251 HMDB 4.4.1.1 false 4.4.1.1 L-Cystathionine + Water → 2-Ketobutyric acid + Ammonium + L-Cysteine LEFT_TO_RIGHT HMDB0000250 HMDB SMILES NCCS(O)(=O)=O SMILES [O-]P([O-])(=O)OP([O-])([O-])=O HMDB0001341 HMDB 10238 PubChem-compound C00042 KEGG Compound L-Cysteine 2.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O 1.0 SMILES C#[N-] SMILES N[C@@H](CCSC[C@H](N)C(O)=O)C(O)=O Putative cysteine synthase SO3 BioCyc Putative cysteine synthase Uncharacterized trans-sulfuration enzyme YHR112C NADPH-dependent diflavin oxidoreductase 1 C10H15N5O13P2S Phosphoadenosine phosphosulfate 506.98624 Thiosulfate sulfurtransferase TUM1 140102 ChemSpider C00177 KEGG Compound SMILES [O-]S([O-])(=O)=O SMILES CC(O)=O C00054 KEGG Compound C00053 KEGG Compound 7732-18-5 CAS 1.0 C00059 KEGG Compound HMDB0001003 HMDB SMILES [S-]C#N 2-iminopropanoate Adenosine phosphosulfate Sulfite reductase [NADPH] subunit beta cytochrome c isoform 2 cytochrome c isoform 1 1.0 C10H16N5O13P3 Adenosine triphosphate 506.99576 CHEBI:18022 ChEBI C00065 KEGG Compound 1.0 10214 PubChem-compound O-Acetylserine 485-84-7 CAS HMDB0001377 HMDB HMDB0001134 HMDB SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(O)=O)[C@@H](OP(O)(O)=O)[C@H]1O SMILES CC(=O)C(O)=O SMILES [O-]S([O-])=O Phosphoadenosine phosphosulfate reductase Alpha-ketoglutarate-dependent sulfonate dioxygenase HMDB0000042 HMDB Eukaryotic peptide chain release factor GTP-binding subunit Adenylyl-sulfate kinase 962 PubChem-compound 5800 ChemSpider Q08686 UniProt Unknown CO2 Carbon dioxide 43.98983 Phosphate C00080 KEGG Compound CHEBI:77456 ChEBI SMILES O=O Oxoglutaric acid 7540-67-2 CAS 1.0 HMDB0002111 HMDB C4H9NO2S Homocysteine 135.0354 1.0 14265-44-2 CAS PYRUVATE BioCyc P00044 UniProt P00045 UniProt 58-64-0 CAS 2-Ketobutyric acid CHEBI:7671 ChEBI 9322 PubChem-compound HOMO-CYS BioCyc C00094 KEGG Compound L-Serine C4H6O3 2-Ketobutyric acid 102.03169 Sulfur Metabolism ACETYLSERINE BioCyc HMDB0000061 HMDB C3H7NO3 L-Serine 105.042595 HMDB0000187 HMDB 644102 PubChem-compound C3H7NO2S L-Cysteine 121.01975 4932 TAXONOMY SMILES NCC=O C00097 KEGG Compound 757 ChemSpider 1.0 513 ChemSpider 22833512 PubChem-compound Homocysteine H2O Water 18.010565 57-12-5 CAS 14265-45-3 CAS 977 PubChem-compound HMDB0059597 HMDB HMDB0041827 HMDB Carbon dioxide 110510 ChemSpider C02291 KEGG Compound cystathionine beta-synthase 17215925 ChemSpider C2H4O2 Acetic acid 60.02113 Reaction2902 true 2-Aminoacrylic acid → 2-iminopropanoate LEFT_TO_RIGHT Reaction2903 true 2-iminopropanoate + Hydrogen Ion + Water → Ammonium + Pyruvic acid LEFT_TO_RIGHT O-acetylhomoserine (thiol)-lyase SMILES N[C@@H](CS)C(O)=O Q12181 UniProt O4S Sulfate 95.95173 5975 PubChem-compound C2H5NO Aminoacetaldehyde 59.037113 Succinic acid C05330 KEGG Compound SMP0002382 SMPDB 4.0 Taurine CNS Thiocyanate 57.975143 64-19-7 CAS Thiosulfate SMILES O Pyrophosphate 5147-00-2 CAS P38716 UniProt HMDB0000538 HMDB 1123 PubChem-compound ReactionCatalysis6903 ACTIVATION ReactionCatalysis6902 ACTIVATION Sulfite ReactionCatalysis6901 ACTIVATION 1.0 ReactionCatalysis6907 ACTIVATION 51 PubChem-compound 89874 ChemSpider ReactionCatalysis6905 ACTIVATION ReactionCatalysis6904 ACTIVATION Adenosine 3',5'-diphosphate Pyruvic acid ADP BioCyc C10H15N5O10P2 Adenosine 3',5'-diphosphate 427.02942 C3H4O3 Pyruvic acid 88.016045 58 PubChem-compound O3S Sulfite 79.95682 49791978 PubChem-compound 1.0 1.0 53-59-8 CAS SMILES CC(=O)OC[C@H](N)C(O)=O ReactionCatalysis6909 ACTIVATION 1038 PubChem-compound ReactionCatalysis6908 ACTIVATION SMILES CC(=N)C([O-])=O Phosphoadenosine phosphosulfate reductase ReactionCatalysis6914 ACTIVATION Adenylyl-sulfate kinase Thiocyanate ReactionCatalysis6913 ACTIVATION ReactionCatalysis6912 ACTIVATION Alpha-ketoglutarate-dependent sulfonate dioxygenase ReactionCatalysis6911 ACTIVATION Eukaryotic peptide chain release factor GTP-binding subunit ReactionCatalysis6916 ACTIVATION SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](O)[C@H]1O 274 ChemSpider ReactionCatalysis6915 ACTIVATION C5H6O5 Oxoglutaric acid 146.02153 391 ChemSpider ReactionCatalysis6910 ACTIVATION 1.0 Sulfate O4P Phosphate 94.95342 NADPH 5862 PubChem-compound SER BioCyc Acetic acid 1948-56-7 CAS Sulfite reductase [NADPH] subunit beta NADPH-dependent diflavin oxidoreductase 1 NADP cytochrome c isoform 1 600-18-0 CAS cytochrome c isoform 2 C21H30N7O17P3 NADPH 745.0911 Putative cysteine synthase 3-5-ADP BioCyc Thiosulfate sulfurtransferase TUM1 302-04-5 CAS Uncharacterized trans-sulfuration enzyme YHR112C C21H29N7O17P3 NADP 744.08325 Putative cysteine synthase oxidized thioredoxin NADPH BioCyc reduced thioredoxin 1053-73-2 CAS HMDB0000208 HMDB CPD-6641 BioCyc 218 ChemSpider C3H4NO2 2-iminopropanoate 86.02475 HMDB0000574 HMDB SMILES [O-]P([O-])([O-])=O SMILES OC(=O)CCC(=O)C(O)=O HMDB0000217 HMDB Oxygen CHEBI:30915 ChEBI 124-38-9 CAS 4.0 HSCN BioCyc HMDB0001429 HMDB HMDB0003609 HMDB 9799 ChemSpider CHEBI:15891 ChEBI SMILES NC(=O)C1=C[N+](=CC=C1)[C@@H]1O[C@H](CO[P@](O)(=O)O[P@](O)(=O)OC[C@H]2O[C@H]([C@H](OP(O)(O)=O)[C@@H]2O)N2C=NC3=C(N)N=CN=C23)[C@@H](O)[C@H]1O 1.0 HMDB0000221 HMDB SMILES NC(=O)C1=CN(C=CC1)[C@H]1O[C@@H](COP(O)(=O)OP(O)(=O)OC[C@@H]2O[C@@H]([C@@H](OP(O)(O)=O)[C@H]2O)N2C=NC3=C(N)N=CN=C23)[C@H](O)[C@@H]1O 6971051 PubChem-compound 159296 PubChem-compound 2.5.1.49,2.5.1.47 false 2.5.1.49,2.5.1.47 Acetylhomoserine + Hydrogen sulfide → Acetic acid + Homocysteine + Hydrogen Ion LEFT_TO_RIGHT 7783-06-4 CAS 4.2.1.22 false 4.2.1.22 Homocysteine + L-Serine → L-Cystathionine + Water LEFT_TO_RIGHT 2.0 CHEBI:17709 ChEBI 1.0 53-57-6 CAS CHEBI:15741 ChEBI SMILES O=C=O CHEBI:28938 ChEBI 5951 PubChem-compound 1110 PubChem-compound C2H7NO3S Taurine 125.01466 O7P2 Pyrophosphate 173.91193 1117 PubChem-compound 1.0 5957 PubChem-compound HMDB0001448 HMDB Q02196 UniProt O3S2 Thiosulfate 111.92889 SMILES NC(CCS)C(O)=O C4H6O4 Succinic acid 118.02661 Aminoacetaldehyde reduced thioredoxin Adenosine diphosphate HMDB0001453 HMDB HMDB0000243 HMDB SMILES N[C@@H](CO)C(O)=O Cyanide C10H15N5O10P2 Adenosine diphosphate 427.02942 L-Cystathionine HMDB0000005 HMDB SMILES CCC(=O)C(O)=O CHN Cyanide 27.010899 C7H14N2O4S L-Cystathionine 222.06743 HMDB0000240 HMDB CHEBI:17985 ChEBI SMILES NC(=C)C(O)=O 3.0 1085 ChemSpider CPD-8587 BioCyc CHEBI:17981 ChEBI 1099 PubChem-compound CHEBI:17980 ChEBI CHEBI:30831 ChEBI oxidized thioredoxin 5.0 1091 ChemSpider P32582 UniProt P31373 UniProt 14000-31-8 CAS 1084 PubChem-compound CHEBI:17514 ChEBI 5675 ChemSpider 1078 ChemSpider SMILES S 14798-03-9 CAS CHEBI:17628 ChEBI Q12358 UniProt NH42SO4 BioCyc CHEBI:15422 ChEBI C00979 KEGG Compound 9821 ChemSpider O2 Oxygen 31.98983 1.0 127-17-3 CAS 1.0 SMILES [NH4+] 107-35-7 CAS CHEBI:16526 ChEBI 1.0 8961 ChemSpider CHEBI:16761 ChEBI 7782-44-7 CAS 1.0 CHEBI:15366 ChEBI 2-KETOGLUTARATE BioCyc sulfate adenylyltransferase 1.0 SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OS(O)(=O)=O)[C@@H](OP(O)(O)=O)[C@H]1O 388392 ChemSpider 8.0 1.0 PAPS BioCyc 2.0 110-15-6 CAS 171 ChemSpider CHEBI:32816 ChEBI CHEBI:15377 ChEBI CHEBI:15379 ChEBI CHEBI:15378 ChEBI SMILES [H+] tryptophanase / L-cysteine desulfhydrase SMILES NC1=NC=NC2=C1N=CN2[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O bifunctional β-cystathionase, PLP-dependent and regulator of maltose regulon 56-45-1 CAS 5886 PubChem-compound O-acetylserine sulfhydrylase A cysteine synthase B thiosulfate sulfurtransferase sulfite reductase 1.0 1.0 3'-phospho-adenylylsulfate reductase 280 PubChem-compound HMDB0000742 HMDB adenylylsulfate kinase 16741146 PubChem-compound 25243997 PubChem-compound 2.7.7.4 false 2.7.7.4 Adenosine triphosphate + Hydrogen Ion + Sulfate → Adenosine phosphosulfate + Pyrophosphate LEFT_TO_RIGHT 1.0 cytochrome c HS BioCyc cystathionine-β-lyase / L-cysteine desulfhydrase SMILES CC(=O)OCCC(N)C(O)=O 1060 PubChem-compound 1061 PubChem-compound C01755 KEGG Compound 4.0 cystathionine gamma-lyase HMDB0001967 HMDB 14383-50-7 CAS 176 PubChem-compound 1.0