Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Vitamin B6
Saccharomyces cerevisiae
Metabolic Pathway
Vitamin B6 belongs to the vitamin B complex group and is water-soluble. The active form is Pyridoxal phosphate (PLP) which acts as a cofactor for various essential enzymes in reactions including: amino acid metabolism, transamination, deamination, and decarboxylation. Other forms of the vitamin include: pyridoxine (PN), pyridoxine 5’-phosphate (PNP), pyridoxal (PL), pyridoxamine (PM), pyridoxamine 5’-phosphate (PMP), and 4-pyridoxic acid (PA). Most animals are unable to synthesize the vitamin while most bacteria are able too. Some organisms also import the vitamin to supplement or augment biosynthesis. S. cerevisiae has transporter Tpn1p on the plasma membrane to import vitamin B6. It transports mostly PN, a precursor of PLP, but also PM and PL. Vitamin B6 is also an antioxidant to provide protection against reactive oxygen species. It has been shown that vitamin B6 synthesis is increased in response to cell stress.
References
Vitamin B6 References
Dong YX, Sueda S, Nikawa J, Kondo H: Characterization of the products of the genes SNO1 and SNZ1 involved in pyridoxine synthesis in Saccharomyces cerevisiae. Eur J Biochem. 2004 Feb;271(4):745-52.
Pubmed: 14764090
Garrido-Franco M: Pyridoxine 5'-phosphate synthase: de novo synthesis of vitamin B6 and beyond. Biochim Biophys Acta. 2003 Apr 11;1647(1-2):92-7.
Pubmed: 12686115
Loubbardi A, Marcireau C, Karst F, Guilloton M: Sterol uptake induced by an impairment of pyridoxal phosphate synthesis in Saccharomyces cerevisiae: cloning and sequencing of the PDX3 gene encoding pyridoxine (pyridoxamine) phosphate oxidase. J Bacteriol. 1995 Apr;177(7):1817-23.
Pubmed: 7896706
Stolz J, Vielreicher M: Tpn1p, the plasma membrane vitamin B6 transporter of Saccharomyces cerevisiae. J Biol Chem. 2003 May 23;278(21):18990-6. doi: 10.1074/jbc.M300949200. Epub 2003 Mar 20.
Pubmed: 12649274
Tsuge H, Ozeki K, Ohashi K: Molecular and Enzymatic Properties of Pyridoxamine (Pyridoxine) 5′-Phosphate Oxidase from Baker’s Yeast. Agricultural And Biological Chemistry. 1980 Oct 01;44(10):2329-2335. doi: 10.1080/00021369.1980.10864322.
Mooney S, Leuendorf JE, Hendrickson C, Hellmann H: Vitamin B6: a long known compound of surprising complexity. Molecules. 2009 Jan 12;14(1):329-51. doi: 10.3390/molecules14010329.
Pubmed: 19145213
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
Settings