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Pathway Description
Isoleucine Degradation
Saccharomyces cerevisiae
Metabolic Pathway
The degradation of isoleucine starts either in the mitochondria or the cytosol. L-isoleucine reacts with 2-oxoglutarate through a branch-chain amino acid aminotransferase resulting in the release of L-glutamate and 3-methyl-2-oxopentanoate. The latter compound reacts with 2-oxoisovalerate carboxy-lyase resulting in the release of carbon dioxide and methylbutanal. Methylbutanal can then be turned into methylbutanol through a alcohol dehydrogenase
References
Isoleucine Degradation References
Dickinson JR: Pathways of leucine and valine catabolism in yeast. Methods Enzymol. 2000;324:80-92.
Pubmed: 10989420
Dickinson JR, Harrison SJ, Dickinson JA, Hewlins MJ: An investigation of the metabolism of isoleucine to active Amyl alcohol in Saccharomyces cerevisiae. J Biol Chem. 2000 Apr 14;275(15):10937-42.
Pubmed: 10753893
Dickinson JR, Salgado LE, Hewlins MJ: The catabolism of amino acids to long chain and complex alcohols in Saccharomyces cerevisiae. J Biol Chem. 2003 Mar 7;278(10):8028-34. doi: 10.1074/jbc.M211914200. Epub 2002 Dec 23.
Pubmed: 12499363
Eden A, Simchen G, Benvenisty N: Two yeast homologs of ECA39, a target for c-Myc regulation, code for cytosolic and mitochondrial branched-chain amino acid aminotransferases. J Biol Chem. 1996 Aug 23;271(34):20242-5.
Pubmed: 8702755
Kispal G, Steiner H, Court DA, Rolinski B, Lill R: Mitochondrial and cytosolic branched-chain amino acid transaminases from yeast, homologs of the myc oncogene-regulated Eca39 protein. J Biol Chem. 1996 Oct 4;271(40):24458-64.
Pubmed: 8798704
Prohl C, Kispal G, Lill R: Branched-chain-amino-acid transaminases of yeast Saccharomyces cerevisiae. Methods Enzymol. 2000;324:365-75.
Pubmed: 10989445
ter Schure EG, Flikweert MT, van Dijken JP, Pronk JT, Verrips CT: Pyruvate decarboxylase catalyzes decarboxylation of branched-chain 2-oxo acids but is not essential for fusel alcohol production by Saccharomyces cerevisiae. Appl Environ Microbiol. 1998 Apr;64(4):1303-7.
Pubmed: 9546164
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