PathWhiz

Pathway Description

Glycerophospholipid Metabolism

Saccharomyces cerevisiae

Metabolic Pathway

The metabolism of glycerophospholipid begins with glycerone phosphate either reacting with glycerol-3-phosphate dehydrogenase resulting in the release of glycerol-3-phosphate or it can react with glycerol-3-phosphate O-acyltransferase / dihydroxyacetone phosphate acyltransferase resulting in the release of a 1-acylglycerone 3-phosphate. Glycerol-3-phosphate reacts with glycerol-3-phosphate O-acyltransferase resulting in the release of an acyl glycerol phosphate. 1-acylglycerone 3-phosphate 1-acyl dihydroxyacetone phosphate reductase resulting in the release of a acyl glycerol phosphate. The latter compound then reacts with a oleoyl-CoA: lysophosphatidate acyltransferase resulting in the release of a phosphatidic acid. The latter compound reacts with Phosphatidic acid phosphohydrolase 1 resulting in the release of diacyl glycerol. This compound can be metabolized through a CTP-dependent diacylglycerol kinase 1 resulting in the release of a phosphatidic acid. Diacyl glycerol reacts with cdp-ethanolamine through a bifunctional diacylglycerol cholinephosphotransferase/ethanolaminephosphotransferase resulting in the release of a phosphatidyl ethanolamine.

References

Glycerophospholipid Metabolism References

Benghezal M, Roubaty C, Veepuri V, Knudsen J, Conzelmann A: SLC1 and SLC4 encode partially redundant acyl-coenzyme A 1-acylglycerol-3-phosphate O-acyltransferases of budding yeast. J Biol Chem. 2007 Oct 19;282(42):30845-55. doi: 10.1074/jbc.M702719200. Epub 2007 Aug 3.

Pubmed: 17675291

Czabany T, Athenstaedt K, Daum G: Synthesis, storage and degradation of neutral lipids in yeast. Biochim Biophys Acta. 2007 Mar;1771(3):299-309. doi: 10.1016/j.bbalip.2006.07.001. Epub 2006 Jul 13.

Pubmed: 16916618

Nagiec MM, Wells GB, Lester RL, Dickson RC: A suppressor gene that enables Saccharomyces cerevisiae to grow without making sphingolipids encodes a protein that resembles an Escherichia coli fatty acyltransferase. J Biol Chem. 1993 Oct 15;268(29):22156-63.

Pubmed: 8408076

Zheng Z, Zou J: The initial step of the glycerolipid pathway: identification of glycerol 3-phosphate/dihydroxyacetone phosphate dual substrate acyltransferases in Saccharomyces cerevisiae. J Biol Chem. 2001 Nov 9;276(45):41710-6. doi: 10.1074/jbc.M104749200. Epub 2001 Sep 5.

Pubmed: 11544256

Carman GM, Han GS: Regulation of phospholipid synthesis in Saccharomyces cerevisiae by zinc depletion. Biochim Biophys Acta. 2007 Mar;1771(3):322-30. doi: 10.1016/j.bbalip.2006.05.006. Epub 2006 May 19.

Pubmed: 16807089

Min-Seok R, Kawamata Y, Nakamura H, Ohta A, Takagi M: Isolation and characterization of ECT1 gene encoding CTP: phosphoethanolamine cytidylyltransferase of Saccharomyces cerevisiae. J Biochem. 1996 Nov;120(5):1040-7.

Pubmed: 8982874

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

		(2E)-Hexadecenoyl-CoA
		1-palmitoylglycerone 3-phosphate
		Adenosine diphosphate
		Adenosine triphosphate
		CDP
		CDP-ethanolamine
		Coenzyme A
		Cytidine monophosphate
		Cytidine triphosphate
		DG(16:0/16:0)
		Ethanolamine
		Glycerol 3-phosphate
		Glycerone phosphate
		Hydrogen Ion
		LysoPA(16:0/0:0)
		NAD
		NADH
		NADP
		NADPH
		O-Phosphoethanolamine
		PA(16:0/16:0)
		Palmitic acid
		Palmitoyl-CoA
		PE(16:0/16:0)
		Phosphate
		Pyrophosphate
		Water

Visualize Protein Data

		Acyl-CoA:lyso-phospholipid acyltransferase
		CTP-dependent diacylglycerol kinase 1
		Ethanolamine kinase
		Ethanolaminephosphotransferase 1
		Glycerol-3-phosphate dehydrogenase
		Glycerol-3-phosphate dehydrogenase GPD2
		Glycerol-3-phosphate O-acyltransferase / Dihydroxyacetone phosphate acyltransferase
		Glycerol-3-phosphate O-acyltransferase 1
		Glycerol-3-phosphate O-acyltransferase 2
		Lipase 4
		Lipase 5
		Lysophosphatidic acid:oleoyl-CoA acyltransferase 1
		NADPH-dependent 1-acyldihydroxyacetone phosphate reductase
		Phosphatidic acid phosphohydrolase 1
		phosphoethanolamine cytidylyltransferase
		Probable 1-acyl-sn-glycerol-3-phosphate acyltransferase

Clear

Downloads

SVG Image

Simple SVG Image

Large Font SVG Image

Simple Large Font SVG Image

Greyscale SVG Image

BioPAX

SBGN

SBML

PWML

PNG Image

All files (.zip)

Settings