The metabolism of choline containing lipids begins with glycerone phosphate either reacting with glycerol-3-phosphate dehydrogenase resulting in the release of glycerol-3-phosphate or it can react with glycerol-3-phosphate O-acyltransferase / dihydroxyacetone phosphate acyltransferase resulting in the release of a 1-acylglycerone 3-phosphate. Glycerol-3-phosphate reacts with glycerol-3-phosphate O-acyltransferase resulting in the release of an acyl glycerol phosphate. 1-acylglycerone 3-phosphate 1-acyl dihydroxyacetone phosphate reductase resulting in the release of a acyl glycerol phosphate. The latter compound then reacts with a oleoyl-CoA: lysophosphatidate acyltransferase resulting in the release of a phosphatidic acid. The latter compound reacts with Phosphatidic acid phosphohydrolase 1 resulting in the release of diacyl glycerol. This compound can be metabolized through a CTP-dependent diacylglycerol kinase 1 resulting in the release of a phosphatidic acid. Phosphatidylcholine is degraded by a phospholipase resulting in the release of choline and phosphatidic acid. Phosphatidylcholine can react with lysophospholipase resulting in the release of two fatty acids and a glycerophosphocholine. The latter compound reacts with a glycerophosphodiester phosphodiesterase resulting in the release of glycerol 3-phosphate and choline. Choline is phosphorylated through a choline kinase resulting in the release of phosphorycholine which can react with choline-phosphate cytidyltransferase resulting in the release of citicoline. The latter compound reacts with a diacylglycerol through a diacylglycerol cholinephosphotransferase resulting in the release of a phosphatidylcholine.

Choline Metabolism References