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Pathway Description
Inositol Metabolism
Saccharomyces cerevisiae
Metabolic Pathway
Inositol (also known as myo-inositol) is a carbocyclic polyol that can be found in many food such as nuts and beans. Inositol (e.g. inositol phosphates, etc.) can act as secondary messengers in eukaryotic cells. Inositol can be synthesized from three resources: inositol monophosphatase 1 can catalyze D-Myo-inositol 4-phosphate, myo-inositol 1-phosphate and 1D-myo-Inositol 3-phosphate to form inositol with water as cofactor.
References
Inositol Metabolism References
Strahl T, Thorner J: Synthesis and function of membrane phosphoinositides in budding yeast, Saccharomyces cerevisiae. Biochim Biophys Acta. 2007 Mar;1771(3):353-404. doi: 10.1016/j.bbalip.2007.01.015. Epub 2007 Feb 6.
Pubmed: 17382260
Garcia-Bustos JF, Marini F, Stevenson I, Frei C, Hall MN: PIK1, an essential phosphatidylinositol 4-kinase associated with the yeast nucleus. EMBO J. 1994 May 15;13(10):2352-61.
Pubmed: 8194527
Guo S, Stolz LE, Lemrow SM, York JD: SAC1-like domains of yeast SAC1, INP52, and INP53 and of human synaptojanin encode polyphosphoinositide phosphatases. J Biol Chem. 1999 May 7;274(19):12990-5.
Pubmed: 10224048
Han GS, Audhya A, Markley DJ, Emr SD, Carman GM: The Saccharomyces cerevisiae LSB6 gene encodes phosphatidylinositol 4-kinase activity. J Biol Chem. 2002 Dec 6;277(49):47709-18. doi: 10.1074/jbc.M207996200. Epub 2002 Oct 1.
Pubmed: 12361950
Stack JH, Emr SD: Vps34p required for yeast vacuolar protein sorting is a multiple specificity kinase that exhibits both protein kinase and phosphatidylinositol-specific PI 3-kinase activities. J Biol Chem. 1994 Dec 16;269(50):31552-62.
Pubmed: 7989323
Yoshida S, Ohya Y, Goebl M, Nakano A, Anraku Y: A novel gene, STT4, encodes a phosphatidylinositol 4-kinase in the PKC1 protein kinase pathway of Saccharomyces cerevisiae. J Biol Chem. 1994 Jan 14;269(2):1166-72.
Pubmed: 8288577
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