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Pathway Description
Lipoic Acid Metabolism
Saccharomyces cerevisiae
Metabolic Pathway
The lipoic acid metabolism involves the metabolism of octanoyl-acp by reacting with a sulfur donor and a S-adenosylmethionine through a lipoic acid synthetase resulting in the release of L-methionine, deoxyadenosine and lipoyl-ACP. Lipoyl-ACP reacts with an apoprotein through a through a lipoyl(octanoyl) transferase resulting in the release of an ACP and a protein N6-(lypoyl)lysine.
Octanoyl-acp can also interact with a apoprotein through a lipoyl(octanoyl) transferase resulting in the release of an ACP and a protein N6-(octanoyl)lysine. Protein N6-(octanoyl) lysine reacts with sulfur donor and a S-adenosylmethionine through a lipoic acid synthetase resulting in the release of L-methionine, deoxyadenosine and Protein N6(lipoyl) lysine.
References
Lipoic Acid Metabolism References
Kanehisa M, Sato Y, Kawashima M, Furumichi M, Tanabe M: KEGG as a reference resource for gene and protein annotation. Nucleic Acids Res. 2016 Jan 4;44(D1):D457-62. doi: 10.1093/nar/gkv1070. Epub 2015 Oct 17.
Pubmed: 26476454
Kanehisa M, Goto S: KEGG: kyoto encyclopedia of genes and genomes. Nucleic Acids Res. 2000 Jan 1;28(1):27-30.
Pubmed: 10592173
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