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Pathway Description
Nitrogen Metabolism
Saccharomyces cerevisiae
Metabolic Pathway
The metabolism of nitrogen in yeast involves ammonia and amino acids. Ammonia and oxoglutaric acid react with glutamate dehydrogenase resulting in the release of glutamic acid. Isocitric acid acid reacts with isocitrate dehydrogenase resulting in the release of Oxoglutaric acid which reacts with glutamine resulting in the release of glutamic acid.
References
Nitrogen Metabolism References
Zhao WN, McAlister-Henn L: Expression and gene disruption analysis of the isocitrate dehydrogenase family in yeast. Biochemistry. 1996 Jun 18;35(24):7873-8. doi: 10.1021/bi9605189.
Pubmed: 8672488
Avendano A, Deluna A, Olivera H, Valenzuela L, Gonzalez A: GDH3 encodes a glutamate dehydrogenase isozyme, a previously unrecognized route for glutamate biosynthesis in Saccharomyces cerevisiae. J Bacteriol. 1997 Sep;179(17):5594-7.
Pubmed: 9287019
Benjamin PM, Wu JI, Mitchell AP, Magasanik B: Three regulatory systems control expression of glutamine synthetase in Saccharomyces cerevisiae at the level of transcription. Mol Gen Genet. 1989 Jun;217(2-3):370-7.
Pubmed: 2570348
DeLuna A, Avendano A, Riego L, Gonzalez A: NADP-glutamate dehydrogenase isoenzymes of Saccharomyces cerevisiae. Purification, kinetic properties, and physiological roles. J Biol Chem. 2001 Nov 23;276(47):43775-83. doi: 10.1074/jbc.M107986200. Epub 2001 Sep 18.
Pubmed: 11562373
Filetici P, Martegani MP, Valenzuela L, Gonzalez A, Ballario P: Sequence of the GLT1 gene from Saccharomyces cerevisiae reveals the domain structure of yeast glutamate synthase. Yeast. 1996 Oct;12(13):1359-66. doi: 10.1002/(SICI)1097-0061(199610)12:13<1359::AID-YEA3>3.0.CO;2-5.
Pubmed: 8923741
Jones EW and Fink GR Regulation of amino acid and nucleotide biosynthesis in yeast. in The Molecular Biology of the Yeast Saccharomyces: Metabolism and Gene Expression, edited by Strathern JN, Jones EW and Broach JR. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory Press (1982) p.181-299
Magasanik, B. Regulation of Nitrogen Utilization. The Molecular and Cellular Biology of the Yeast Saccharomyces: Gene Expression (1992) 2, p.283-317
Moye WS, Amuro N, Rao JK, Zalkin H: Nucleotide sequence of yeast GDH1 encoding nicotinamide adenine dinucleotide phosphate-dependent glutamate dehydrogenase. J Biol Chem. 1985 Jul 15;260(14):8502-8.
Pubmed: 2989290
Valenzuela L, Ballario P, Aranda C, Filetici P, Gonzalez A: Regulation of expression of GLT1, the gene encoding glutamate synthase in Saccharomyces cerevisiae. J Bacteriol. 1998 Jul;180(14):3533-40.
Pubmed: 9657994
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