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Pathway Description

Stress-Activated Signalling Pathways: Low Osmolarity

Saccharomyces cerevisiae

Protein Pathway

Stress-activated protein kinase pathways in Saccharomyces. The HOG1 MAPK pathway is controlled by two separate osmosensors, SLN1 and SHO1. Sln1 is activated in low osmolarity, thus repressing Ssk1 by phosphorylating it. Ssk1 is in charge of activating Ssk2/22 which in turn activates Pbs2 and in turn activates Hog1. SHO1 is activated during high osmolarity, resulting in Ste11 being activated, which in turn activates Pbs2 and activates Hog1. Ptp2 and Ptp3 negatively regulates Hog1.

References

Stress-Activated Signalling Pathways: Low Osmolarity References

Toone WM, Jones N: Stress-activated signalling pathways in yeast. Genes Cells. 1998 Aug;3(8):485-98.

Pubmed: 9797451

Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.

Visualize Compound Data

Phosphate

Visualize Protein Data

		High osmolarity signaling protein SHO1
		MAP kinase kinase kinase SSK2
		MAP kinase kinase PBS2
		Mitogen-activated protein kinase HOG1
		Osmolarity two-component system protein SSK1
		Osmosensing histidine protein kinase SLN1
		Phosphorelay intermediate protein YPD1
		Serine/threonine-protein kinase SSK22
		Tyrosine-protein phosphatase 1
		Tyrosine-protein phosphatase 2

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