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Pathway Description
Stress-activated signalling pathways: high osmolarity test 1
Saccharomyces cerevisiae
Signaling Pathway
Stress-activated protein kinase pathways in Saccharomyces. The HOG1 MAPK pathway is controlled by two separate osmosensors, SLN1 and SHO1. Sln1 is activated in low osmolarity, thus repressing Ssk1 by phosphorylating it. Ssk1 is in charge of activating Ssk2/22 which in turn activates Pbs2 and in turn activates Hog1. SHO1 is activated during high osmolarity, resulting in Ste11 being activated, which in turn activates Pbs2 and activates Hog1. Ptp2 and Ptp3 negatively regulates Hog1.
References
Stress-activated signalling pathways: high osmolarity test 1 References
Toone WM, Jones N: Stress-activated signalling pathways in yeast. Genes Cells. 1998 Aug;3(8):485-98.
Pubmed: 9797451
Hohmann S: Osmotic stress signaling and osmoadaptation in yeasts. Microbiol Mol Biol Rev. 2002 Jun;66(2):300-72.
Pubmed: 12040128
Yamamoto K, Tatebayashi K, Tanaka K, Saito H: Dynamic control of yeast MAP kinase network by induced association and dissociation between the Ste50 scaffold and the Opy2 membrane anchor. Mol Cell. 2010 Oct 8;40(1):87-98. doi: 10.1016/j.molcel.2010.09.011.
Pubmed: 20932477
Tatebayashi K, Yamamoto K, Tanaka K, Tomida T, Maruoka T, Kasukawa E, Saito H: Adaptor functions of Cdc42, Ste50, and Sho1 in the yeast osmoregulatory HOG MAPK pathway. EMBO J. 2006 Jul 12;25(13):3033-44. doi: 10.1038/sj.emboj.7601192. Epub 2006 Jun 15.
Pubmed: 16778768
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