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Osmosensing histidine protein kinase SLN1 Phosphorelay intermediate protein YPD1 High osmolarity signaling protein SHO1 Signalling mucin HKR1 Signaling mucin MSB2 Cell division control protein 42 CDC42 Cell division control protein 24 CDC24 OPY2 STE50 Serine/threonine- protein kinase STE20 Serine/threonine- protein kinase CLA4 Tyrosine- protein phosphatase 2 Tyrosine- protein phosphatase 3 Protein phosphatase 2C homolog 1 Protein SIC1 S-phase entry cyclin-5 S-phase entry cyclin-6 Cyclin- dependent kinase 1 Serine/threonine- protein kinase HSL1 Protein arginine N- methyltransferase HSL7 Mitosis inhibitor protein kinase SWE1 G2/mitotic- specific cyclin-1 G2/mitotic- specific cyclin-2 CLB2 Cyclin- dependent kinase 1 CRE-binding bZIP protein SKO1 General transcriptional corepressor CYC8 General transcriptional corepressor TUP1 NADPH-dependent methylglyoxal reductase High- osmolarity- induced transcription protein 1 HOT1 Transcription factor SMP1 Glycerol-3- phosphate dehydrogenase [NAD(+)] 1 Zinc finger protein MSN2 Zinc finger protein MSN4 Pheromone receptor transcription factor MCM1 Catalase T CTT1 Osmolarity two-component system protein SSK1 Phosphorylated MAP kinase kinase kinase SSK2 Serine/threonine- protein kinase SSK22 Unknown Unknown Serine/threonine- protein kinase STE11 MAP kinase kinase PBS2 Mitogen- activated protein kinase HOG1 P i P i P i P i P i P i P i P i P i P i P i P i P i P i P i P i P i High Osmolarity DNA DNA DNA Cell Arrest Cycle Osmolyte Synthesis
SLN1 YPD1 SHO1 HKR1 MSB2 CDC42 CDC24 OPY2 STE50 STE20 CLA4 PTP2 PTP3 PTC1 SIC1 CLB5 CLB6 CDC28 HSL1 HSL7 SWE1 CLB1 CLB2 CDC28 SKO1 CYC8 TUP1 GRE2 HOT1 SMP1 GPD1 MSN2 MSN4 MCM1 CTT1 Unknown Unknown Unknown Unknown Unknown Unknown Unknown Unknown Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate Phosphate