Lysolipid Incorporation into Mitochondria PC(18:2(9Z,11Z)/18:2(9Z,11Z))
Saccharomyces cerevisiae
Metabolic Pathway
Lysolipids such as lysophosphatidylethanolamine, lysophosphatidylcholine, lysophosphatidylserine and lysophosphatidylinositol get transported into the cell through a phospholipid ATPase. Once in the cytosol they are incorporated into the mitochondria membrane through a Ale1p transport membrane where phosphatidylcholine is generated.
References
Lysolipid Incorporation into Mitochondria PC(18:2(9Z,11Z)/18:2(9Z,11Z)) References
Riekhof WR, Wu J, Gijon MA, Zarini S, Murphy RC, Voelker DR: Lysophosphatidylcholine metabolism in Saccharomyces cerevisiae: the role of P-type ATPases in transport and a broad specificity acyltransferase in acylation. J Biol Chem. 2007 Dec 21;282(51):36853-61. doi: 10.1074/jbc.M706718200. Epub 2007 Oct 21.
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
