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Endoplasmic Reticulum Phosphatidic acid phosphohydrolase 1 CTP-dependent diacylglycerol kinase 1 Lipase 3 Monoglyceride lipase Glycerol-3- phosphate O- acyltransferase 2 glycerol-3- phosphate O- acyltransferase / dihydroxyacetone phosphate acyltransferase acyl- CoA:lyso- phospholipid acyltransferase Lipase 4 Probable 1-acyl-sn- glycerol-3- phosphate acyltransferase Lipase 5 Lysophosphatidic acid:oleoyl-CoA acyltransferase 1 Diacylglycerol O- acyltransferase 1 Sterol esterase TGL1 Lipase 2 Lipase 3 Lipase 4 Lipase 5 PA(18:0/18:0) H 2 O DG(18:0/20:0/0:0) P i Cytidine triphosphate H + CDP DG(18:0/20:0/0:0) H 2 O H + Palmitic acid MG(18:0/0:0/0:0) H 2 O Palmitic acid H + Glycerol MG(18:0/0:0/0:0) TG(18:0/18:0/20:0) Glycerol 3-phosphate CoA LPA(18:0/0:0) CoA CoA H 2 O H + long-chain fatty acyl-CoA long-chain fatty acyl-CoA long-chain fatty acyl-CoA long-chain fatty acyl-CoA Fatty Acid Glycerol-3- phosphate O- acyltransferase 1
Endoplasmic Reticulum PAH1 DGK1 TGL3 YJU3 GTP2 GPT2, GAT1 ALE1 TGL4 SLC1 TGL5 LOA1 DGA1 TGL1 TGL2 TGL3 TGL4 TGL5 PA(18:0/18:0) Water DG(18:0/20:0/0:0) Phosphate Cytidine triphosphate Hydrogen Ion CDP DG(18:0/20:0/0:0) Water Hydrogen Ion Palmitic acid MG(18:0/0:0/0:0) Water Palmitic acid Hydrogen Ion Glycerol MG(18:0/0:0/0:0) TG(18:0/18:0/20:0) Glycerol 3-phosphate Coenzyme A LPA(18:0/0:0) Coenzyme A Coenzyme A Water Hydrogen Ion long-chain fatty acyl-CoA long-chain fatty acyl-CoA long-chain fatty acyl-CoA long-chain fatty acyl-CoA Fatty Acid SCT1