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Pathway Description
Triacylglycerol Metabolism TG(10:0/22:0/25:0)
Saccharomyces cerevisiae
Metabolic Pathway
A triglyceride (TG, triacylglycerol, TAG, or triacylglyceride) is an ester derived from glycerol and three fatty acids. The biosynthesis of triacylglycerol is localized to the endoplasmic reticulum membrane and starts with glycerol 3-phosphate reacting with acyl-CoA through a glycerol-3-phosphate O-acyltransferase resulting in the release of lysophosphatidic acid (LPA). This, in turn, reacts with an acyl-CoA through a lipase complex resulting in the release of CoA and phosphatidic acid. Phosphatidic acid reacts with water through a phosphatidic acid phosphohydrolase 1 resulting in the release of a phosphate and a diacylglycerol. This reaction can be reversed through a CTP-dependent diacylglycerol kinase. The diacylglycerol reacts in the endoplasmic reticulum with an acyl-CoA through a diacylglycerol O-acyltransferase resulting in the release of coenzyme A and a triacylglycerol. Triacylglycerol metabolism begins with a reaction with water through lipase resulting in the release of a fatty acid, hydrogen ion, and a diacylglycerol. Diacylglycerol then reacts with a lipase 3 resulting in the release of a fatty acid and a monoacylglycerol. Monoacylglycerol reacts with monoglyceride lipase resulting in the release of a fatty acid in glycerol.
References
Triacylglycerol Metabolism TG(10:0/22:0/25:0) References
Athenstaedt K, Zweytick D, Jandrositz A, Kohlwein SD, Daum G: Identification and characterization of major lipid particle proteins of the yeast Saccharomyces cerevisiae. J Bacteriol. 1999 Oct;181(20):6441-8.
Pubmed: 10515935
Czabany T, Athenstaedt K, Daum G: Synthesis, storage and degradation of neutral lipids in yeast. Biochim Biophys Acta. 2007 Mar;1771(3):299-309. doi: 10.1016/j.bbalip.2006.07.001. Epub 2006 Jul 13.
Pubmed: 16916618
Kurat CF, Natter K, Petschnigg J, Wolinski H, Scheuringer K, Scholz H, Zimmermann R, Leber R, Zechner R, Kohlwein SD: Obese yeast: triglyceride lipolysis is functionally conserved from mammals to yeast. J Biol Chem. 2006 Jan 6;281(1):491-500. doi: 10.1074/jbc.M508414200. Epub 2005 Nov 2.
Pubmed: 16267052
Henry SA, Kohlwein SD, Carman GM: Metabolism and regulation of glycerolipids in the yeast Saccharomyces cerevisiae. Genetics. 2012 Feb;190(2):317-49. doi: 10.1534/genetics.111.130286.
Pubmed: 22345606
This pathway was generated using PathWhiz -
Pon, A. et al. Pathways with PathWhiz (2015) Nucleic Acids Res. 43(Web Server issue): W552–W559.
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