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Pathway Description
Wnt/LRP6 Signalling
Homo sapiens
Signaling Pathway
Canonical Wnt/β-catenin signaling has central roles in development and diseases, and is initiated by the action of the frizzled (Fz) receptor, its coreceptor LDL receptor-related protein 6 (Lrp6), and the cytoplasmic dishevelled (Dvl) protein. The functional relationships among Fz, Lrp6 and Dvl have long been enigmatic. Wnt-induced Lrp6 phosphorylation via glycogen synthase kinase 3 (Gsk3) initiates Wnt/β-catenin signaling. Both Fz and Dvl functions are critical for Wnt-induced Lrp6 phosphorylation through Fz-Lrp6 interaction.
References
Wnt/LRP6 Signalling References
Zeng X, Huang H, Tamai K, Zhang X, Harada Y, Yokota C, Almeida K, Wang J, Doble B, Woodgett J, Wynshaw-Boris A, Hsieh JC, He X: Initiation of Wnt signaling: control of Wnt coreceptor Lrp6 phosphorylation/activation via frizzled, dishevelled and axin functions. Development. 2008 Jan;135(2):367-75. doi: 10.1242/dev.013540. Epub 2007 Dec 12.
Pubmed: 18077588
Acebron SP, Niehrs C: beta-Catenin-Independent Roles of Wnt/LRP6 Signaling. Trends Cell Biol. 2016 Dec;26(12):956-967. doi: 10.1016/j.tcb.2016.07.009. Epub 2016 Aug 24.
Pubmed: 27568239
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