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Unknown Unknown Choline dehydrogenase, mitochondrial Alpha- aminoadipic semialdehyde dehydrogenase Betaine-- homocysteine S- methyltransferase 1 Methionine synthase S- adenosylmethionine synthase isoform type-2 Methionine adenosyltransferase 2 subunit beta Glycine N- methyltransferase Serine hydroxymethyltransferase, cytosolic Dimethylglycine dehydrogenase, mitochondrial Sarcosine dehydrogenase, mitochondrial Serine hydroxymethyltransferase, mitochondrial Choline Choline βine βine Dimethylglycine Dimethylglycine βine aldehyde NAD H2O NADH Homocysteine L-Methionine Homocysteine 5- Methyltetrahydrofolic acid Tetrahydrofolic acid ATP H2O S- Adenosylmethionine Pi PPi Sarcosine S- Adenosylhomocysteine Glycine L-Serine Tetrahydrofolic acid 5,10- Methylene-THF H2O Tetrahydrofolate Sarcosine 5- Methyltetrahydrofolic acid Tetrahydrofolate 5- Methyltetrahydrofolic acid Glycine L-Serine Tetrahydrofolate 5- Methyltetrahydrofolic acid FAD Zinc (II) ion Zinc (II) ion Magnesium Potassium Pyridoxal 5'-phosphate FAD FAD Pyridoxal 5'-phosphate Acceptor Reduced acceptor Intracellular space Mitochondrion Outer Mitochondrial Membrane Inner Mitochondrial Membrane Upregulated Expression Mutant SARDH
Mitochondria Unknown Unknown Chdh Aldh7a1 Bhmt Mtr Mat2a Mat2b Gnmt Shmt1 Dmgdh Sardh Shmt2 Choline Choline βine βine Dimethylglycine Dimethylglycine βine aldehyde NAD Water NADH Homocysteine L-Methionine Homocysteine 5- Methyltetrahydrofolic acid Tetrahydrofolic acid Adenosine triphosphate Water S- Adenosylmethionine Phosphate Pyrophosphate Sarcosine S- Adenosylhomocysteine Glycine L-Serine Tetrahydrofolic acid 5,10- Methylene-THF Water Tetrahydrofolate Sarcosine 5- Methyltetrahydrofolic acid Tetrahydrofolate 5- Methyltetrahydrofolic acid Glycine L-Serine Tetrahydrofolate 5- Methyltetrahydrofolic acid Acceptor Reduced acceptor
Chdh Aldh7a1 Bhmt Mtr Mat2a Mat2b Gnmt Shmt1 Dmgdh Sardh Shmt2 Choline Choline βine βine DMglyc DMglyc BinAld NAD H2O NADH Hcys Met Hcys 5-MTHFa THFA ATP H2O SAMe Pi PPi Sar SAH Gly Ser THFA 5XM-THF H2O tethf Sar 5-MTHFa tethf 5-MTHFa Gly Ser tethf 5-MTHFa FAD Zinc Zinc Mg2+ K+ Pyr-5'P FAD FAD Pyr-5'P Accepto RA Intracellular space Mitochondrion Outer Mitochondrial Membrane Inner Mitochondrial Membrane Upregulated Expression Mutant SARDH
Mitochondria Chdh Aldh7a1 Bhmt Mtr Mat2a Mat2b Gnmt Shmt1 Dmgdh Sardh Shmt2 Choline Choline βine βine DMglyc DMglyc BinAld NAD H2O NADH Hcys Met Hcys 5-MTHFa THFA ATP H2O SAMe Pi Ppi Sar SAH Gly Ser THFA 5XM-THF H2O tethf Sar 5-MTHFa tethf 5-MTHFa Gly Ser tethf 5-MTHFa Accepto RA