Loading Pathway...
Error: Pathway image not found.
Hide
Pathway Description
Streptomycin Action Pathway (New)
Homo sapiens
Drug Action Pathway
Streptomycin is an antibiotic that treats multi-drug-resistant bacterial strains. It is in the aminoglycosides family and it is derived from Streptomyces griseus which was the first effective antibiotic against Mycobacterium tuberculosis. It is now largely a second-line option due to the development of resistance and toxicity. Streptomycin goes through 3 phases in order to infiltrate the bacterial cell and inhibit protein synthesis: the first phase is the binding of polycationic drug to the negatively charged bacterial cell membrane which increases membrane permeability. The second phase is the entry of aminoglycoside through oxygen-dependent active transport into the cell where it then travels and binds to the 16rRNA and 30S ribosomal subunit. The final phase is the inhibition of protein synthesis and the accumulation of Streptomycin in the cell which further exacerbates its inhibition of protein synthesis, elongation, and ribosome recycling. It is mainly used in combination with other antibiotics. It is commonly administered via intramuscular injection or intravenously and is eliminated in the urine 24 hours after its administration into the body. Some caution must be taken with streptomycin as overdose can lead to nephrotoxicity and ototoxicity.
References
Streptomycin Pathway (New) References
Block M, Blanchard DL: Aminoglycosides.
Pubmed: 31082149
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Waters M, Tadi P: Streptomycin.
Pubmed: 32310346
Adeyemo AA, Oluwatosin O, Omotade OO: Study of streptomycin-induced ototoxicity: protocol for a longitudinal study. Springerplus. 2016 Jun 17;5(1):758. doi: 10.1186/s40064-016-2429-5. eCollection 2016.
Pubmed: 27386243
Serio AW, Keepers T, Andrews L, Krause KM: Aminoglycoside Revival: Review of a Historically Important Class of Antimicrobials Undergoing Rejuvenation. EcoSal Plus. 2018 Nov;8(1). doi: 10.1128/ecosalplus.ESP-0002-2018.
Pubmed: 30447062
Hancock RE, Raffle VJ, Nicas TI: Involvement of the outer membrane in gentamicin and streptomycin uptake and killing in Pseudomonas aeruginosa. Antimicrob Agents Chemother. 1981 May;19(5):777-85. doi: 10.1128/AAC.19.5.777.
Pubmed: 6794444
Davis BD, Chen LL, Tai PC: Misread protein creates membrane channels: an essential step in the bactericidal action of aminoglycosides. Proc Natl Acad Sci U S A. 1986 Aug;83(16):6164-8. doi: 10.1073/pnas.83.16.6164.
Pubmed: 2426712
Wallace BJ, Tai PC, Herzog EL, Davis BD: Partial inhibition of polysomal ribosomes of Escherichia coli by streptomycin. Proc Natl Acad Sci U S A. 1973 Apr;70(4):1234-7. doi: 10.1073/pnas.70.4.1234.
Pubmed: 4577795
Tai PC, Wallace BJ, Davis BD: Streptomycin causes misreading of natural messenger by interacting with ribosomes after initiation. Proc Natl Acad Sci U S A. 1978 Jan;75(1):275-9. doi: 10.1073/pnas.75.1.275.
Pubmed: 343106
Germovsek E, Barker CI, Sharland M: What do I need to know about aminoglycoside antibiotics? Arch Dis Child Educ Pract Ed. 2017 Apr;102(2):89-93. doi: 10.1136/archdischild-2015-309069. Epub 2016 Aug 9.
Pubmed: 27506599
Highlighted elements will appear in red.
Highlight Compounds
Highlight Proteins
No Proteins Present
Enter relative concentration values (without units). Elements will be highlighted in a color gradient where red = lowest concentration and green = highest concentration. For the best results, view the pathway in Black and White.
Visualize Compound Data
Visualize Protein Data
No Proteins Present
Clear
Downloads
Settings