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Pathway Description
Apixaban Action Pathway
Homo sapiens
Drug Action Pathway
Apixaban (brand name Eliquis) is an oral anticoagulant drug that is a competitive inhibitor of free and bound factor Xa in the coagulation cascade. These effects will prevent the formation of a thrombus. This oral drug is typically used for the prevention of strokes or systemic embolism. It is also indicated in the treatment and reduction in risk of recurrent thromboembolic diseases, such as Deep Vein Thrombosis (DVT) and Pulmonary Embolisms (PE).
Apixaban is a substrate for both CYP3A4 and P-glycoprotein (P-gp) and is known to increase in the blood when these are inhibited. Apixaban enters the bloodstream through the intestine by P-gp transport.
References
Apixaban Pathway References
Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.
Pubmed: 29126136
Vranckx P, Valgimigli M, Heidbuchel H: The Significance of Drug-Drug and Drug-Food Interactions of Oral Anticoagulation. Arrhythm Electrophysiol Rev. 2018 Mar;7(1):55-61. doi: 10.15420/aer.2017.50.1.
Pubmed: 29636974
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