PathWhiz

Pathway Description

Alfentanil Metabolism Pathway

Homo sapiens

Metabolic Pathway

Alfentanil is used to induce and maintain anesthesia, as well as an analgesic. Alfentanil is a short-acting opioid anesthetic and analgesic derivative of fentanyl. It produces an early peak analgesic effect and fast recovery of consciousness. Alfentanil is effective as an anesthetic during surgery, for supplementation of analgesia during surgical procedures, and as an analgesic for critically ill patients. It is administered by intravenous injection or infusion. The liver is the major site of metabolism where it metabolised to noralfentanil, 2-(4-ethyl-5-oxo-1,2,3,4-tetrazol-1-yl)acetaldehyde, N-phenylpropionamide and AMX (Ci.I yellow pigment) and excreted in urine via the kidneys. Only 1.0% of the dose is excreted as unchanged drug.

References

Alfentanil Metabolism Pathway References

Wishart DS, Feunang YD, Guo AC, Lo EJ, Marcu A, Grant JR, Sajed T, Johnson D, Li C, Sayeeda Z, Assempour N, Iynkkaran I, Liu Y, Maciejewski A, Gale N, Wilson A, Chin L, Cummings R, Le D, Pon A, Knox C, Wilson M: DrugBank 5.0: a major update to the DrugBank database for 2018. Nucleic Acids Res. 2018 Jan 4;46(D1):D1074-D1082. doi: 10.1093/nar/gkx1037.

Highlighted elements will appear in red.

Highlight Compounds

	2-(4-ethyl-5-oxo-1,2,3,4-tetrazol-1-yl)acetaldehyde
	Alfentanil
	C.I. Pigment Yellow
	Heme
	N-phenylpropionamide
	Noralfentanil

Highlight Proteins

	Cytochrome P450 3A4
	Multidrug resistance-associated protein 4
	Solute carrier family 22 member 1

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