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Pathway Description
Antihemophilic Factor Human Action Pathway
Homo sapiens
Drug Action Pathway
Antihemophilic factor human, also known as Hemofil, Koate, and Wilate is used as factor VIII replacement therapy to treat hemophilia A. It is a non-recombinant concentrate of the endogenous coagulation factor VIII, produced by reducing von Willebrand Factor antigen and purified by affinity chromatography. Hemophilia A is caused by mutations in the coagulation factor VIII gene that leads to functional deficiency and or complete loss of the coagulation factor. These mutations lead to bleeding and being able to bruise easily, exogenous replacement of coagulation factor VIII in order to counteract the deficiencies. Administered intravenously the antihemophilic factor human replaces the abnormal coagulation factor VIII, acting as a cofactor to activate coagulation factor IX and X.
References
Antihemophilic Factor Human Pathway References
Nogami K: Bispecific antibody mimicking factor VIII. Thromb Res. 2016 May;141 Suppl 2:S34-5. doi: 10.1016/S0049-3848(16)30361-9.
Pubmed: 27207420
Morfini M: The History of Clotting Factor Concentrates Pharmacokinetics. J Clin Med. 2017 Mar 20;6(3):35. doi: 10.3390/jcm6030035.
Pubmed: 28335525
Hazendonk H, Fijnvandraat K, Lock J, Driessens M, van der Meer F, Meijer K, Kruip M, Gorkom BL, Peters M, de Wildt S, Leebeek F, Cnossen M, Mathot R: A population pharmacokinetic model for perioperative dosing of factor VIII in hemophilia A patients. Haematologica. 2016 Oct;101(10):1159-1169. doi: 10.3324/haematol.2015.136275. Epub 2016 Jul 6.
Pubmed: 27390359
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