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Unknown Unknown KISS1 Unknown Unknown Unknown Early growth response protein 1 Unknown Unknown Unknown Unknown Catenin beta-1 Proto-oncogene c-Fos Unknown Glycoprotein hormones alpha chain Unknown Lutropin- choriogonadotropic hormone receptor Unknown Glycoprotein hormones alpha chain Follicle- stimulating hormone receptor Guanine nucleotide- binding protein G(s) subunit alpha isoforms short Guanine nucleotide- binding protein G(I)/G(S)/G(O) subunit gamma-12 Guanine nucleotide- binding protein G(i) subunit alpha-1 Guanine nucleotide- binding protein G(I)/G(S)/G(T) subunit beta-1 Adenylate cyclase type 5 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta Adenylate cyclase type 5 cAMP-dependent protein kinase catalytic subunit alpha cAMP-dependent protein kinase catalytic subunit beta cAMP-dependent protein kinase catalytic subunit alpha Unknown Aromatase Unknown Unknown Unknown Gnrh1 Unknown Cyp11a1 Cyp17a1 3-beta-HSD 1 Testosterone 17-beta- dehydrogenase 3 Aromatase Estradiol 17-beta- dehydrogenase 1 Unknown Cytochrome P450 1A1 3-beta-HSD 1 Steroid 17-alpha- hydroxylase/17,20 lyase Steroid 17-alpha- hydroxylase/17,20 lyase 3-beta-HSD 1 Estradiol 17-beta- dehydrogenase 1 3-beta-HSD 1 Testosterone 17-beta- dehydrogenase 3 Steroid 17-alpha- hydroxylase/17,20 lyase Unknown Inositol 1,4,5-trisphosphate cAMP cAMP Progesterone Progesterone Androstenedione Androstenedione Testosterone Testosterone Cholesterol PIP2(16:0/16:2(9Z,12Z)) H2O 1,2-Diacyl-sn-glycerol (dioctadecanoyl, n-C18:0) Cholesterol Pregnenolone 17a-Hydroxypregnenolone Estrone 17β-estradiol 4-Hydroxyestradiol 2-Hydroxyestradiol ATP PPi ATP PPi 17-Hydroxyprogesterone Dehydroepiandrosterone 5-Androstenediol PIP2(16:0/16:2(9Z,12Z)) K+ K+ Magnesium Magnesium Heme Heme Heme Heme Erk1/Erk2 Mapk Signaling pathway Heme Heme Ca+ Heme Heme Hypothalamus Kisspeptin neuron GnRH neuron Anterior Pituitary Gland Depolarization Ovaries Theca Cell Granulosa Cell Steroidogenesis Mitochondria Nucleus Nucleus Nucleus Blood Vessel Estrogen Synthesis Progesterone binds with high affinity to the progesterone receptor. This inhibits and slow the release of GnRH from the hypothalamus. The preceding step of a LH surge to activate ovulation is suppressed. Kisspeptin neuron The transcription of proteins like glycoprotein hormones (FSH and LH) is inhibited since there is less GnRH. Those glycoproteins will be less available in the blood. The low level of transcription of the LH and FSH hormones results in the inhibition of the ovulation (release of an egg by the ovary) that needs the surge of those hormones. Progesterone is a naturally occuring hormone Brain
Nucleus Unknown Unknown Unknown Unknown Unknown Unknown Egr1 Unknown Unknown Unknown Unknown Ctnnb1 Fos Unknown Cga Unknown Lhcgr Unknown Cga Fshr GNAS GNB1 GNG12 Gnai1 GNB1 GNG2 Adcy5 Prkaca Prkaca PRKACB Adcy5 Prkaca PRKACB Prkaca Unknown Cyp19a1 Unknown Unknown Unknown Gnrh1 Unknown Cyp11a1 Cyp17a1 Hsd3b5 Hsd17b3 Cyp19a1 Hsd17b1 Unknown Cyp1a1 Hsd3b5 Cyp17a1 Cyp17a1 Hsd3b5 Hsd17b1 Hsd3b5 Hsd17b3 Cyp17a1 Unknown Inositol 1,4,5- trisphosphate cAMP cAMP Progesterone Progesterone Androstenedione Androstenedione Testosterone Testosterone Cholesterol PIP2(16:0/16:2(9Z,12Z)) Water 1,2-Diacyl- sn-glycerol (dioctadecanoyl, n-C18:0) Cholesterol Pregnenolone 17a- Hydroxypregnenolone Estrone 17β-estradiol 4- Hydroxyestradiol 2- Hydroxyestradiol Adenosine triphosphate Pyrophosphate Adenosine triphosphate Pyrophosphate 17- Hydroxyprogesterone Dehydroepiandrosterone 5- Androstenediol PIP2(16:0/16:2(9Z,12Z)) Potassium Potassium Erk1/Erk2 Mapk Signaling pathway Calcium
Nucleus Egr1 Ctnnb1 Fos Cga Lhcgr Cga Fshr GNAS GNB1 GNG12 Gnai1 GNB1 GNG2 Adcy5 Prkaca Prkaca PRKACB Adcy5 Prkaca PRKACB Prkaca Cyp19a1 Gnrh1 Cyp11a1 Cyp17a1 Hsd3b5 Hsd17b3 Cyp19a1 Hsd17b1 Cyp1a1 Hsd3b5 Cyp17a1 Cyp17a1 Hsd3b5 Hsd17b1 Hsd3b5 Hsd17b3 Cyp17a1 Inotp cAMP cAMP Prgstrn Prgstrn Adione Adione Oreton Oreton Lanol PIP2(32 H2O DG Lanol Pregnen 17a-HP Estrone 17β-est 4Ohe2 Ecs ATP Ppi ATP Ppi 17-OHP DHEA Tetrabo PIP2(32 K+ K+ PW064771 Ca2+