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Cytochrome P450 3A4 Vincristine Vincristine Vincristine PIS1M1 Vincristine PIS1M1 Urinary Excretion and/or Bile duct Excretion Heme Hepatocytes Kidney Liver Cytosol Vincristine undergoes metabolism to give Vincristine PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 Vincristine Vincristine Vincristine PIS1M1 Vincristine PIS1M1 Urinary Excretion and/or Bile duct Excretion
CYP3A4 VnCrt VnCrt Vin PIS Vin PIS U E a B Heme Hepatocytes Kidney Liver Cytosol Vincristine undergoes metabolism to give Vincristine PIS1M1. Endoplasmic Reticulum Bile Ducts Blood Vessel Blood Vessel
Endoplasmic Reticulum CYP3A4 VnCrt VnCrt Vin PIS Vin PIS U E a B