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Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Telotristat ethyl PIS2M1 Telotristat ethyl Telotristat ethyl Telotristat ethyl PIS1M1 Telotristat ethyl PIS2M1 Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Telotristat ethyl undergoes metabolism to give Telotristat ethyl PIS1M1 and Telotristat ethyl PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown CYP3A4 CYP3A4 Telotristat ethyl PIS2M1 Telotristat ethyl Telotristat ethyl Telotristat ethyl PIS1M1 Telotristat ethyl PIS2M1 Urinary Excretion and/or Bile duct Excretion