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Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Brexpiprazole PIS2M1 Brexpiprazole PIS2M1 Brexpiprazole PIS1M1 Brexpiprazole PIS1M1 Brexpiprazole Brexpiprazole Brexpiprazole PIS1M2 Heme Heme Urinary Excretion and/or Bile duct Excretion Heme Endoplasmic Reticulum Cytosol Hepatocyte Endoplasmic Reticulum Liver Blood Vessel Kidney Bile Ducts Blood Vessel Brexpiprazole undergoes metabolism to give Brexpiprazole PIS1M1, Brexpiprazole PIS1M2 and Brexpiprazole PIS2M1.
Endoplasmic Reticulum Endoplasmic Reticulum Unknown CYP3A4 CYP3A4 CYP3A4 Brexpiprazole PIS2M1 Brexpiprazole PIS2M1 Brexpiprazole PIS1M1 Brexpiprazole PIS1M1 Brexpiprazole Brexpiprazole Brexpiprazole PIS1M2 Urinary Excretion and/or Bile duct Excretion