Loader
Loading Pathway...
Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Sarecycline Sarecycline Sarecycline PIS2M1 Sarecycline PIS2M1 Sarecycline PIS4M1 Sarecycline PIS4M1 Sarecycline PIS1M1 Sarecycline PIS2M2 Sarecycline PIS1M2 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Sarecycline undergoes metabolism to give Sarecycline PIS1M1, Sarecycline PIS1M2, Sarecycline PIS1M3, Sarecycline PIS1M4 and Sarecycline PIS2M1. Endoplasmic Reticulum Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Sarecycline Sarecycline Sarecycline PIS2M1 Sarecycline PIS2M1 Sarecycline PIS4M1 Sarecycline PIS4M1 Sarecycline PIS1M1 Sarecycline PIS2M2 Sarecycline PIS1M2 Urinary Excretion and/or Bile duct Excretion