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Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Telithromycin Telithromycin Telithromycin PIS2M1 Telithromycin PIS2M1 Telithromycin PIS4M1 Telithromycin PIS4M1 Telithromycin PIS1M2 Telithromycin PIS2M2 Telithromycin PIS1M1 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Telithromycin undergoes metabolism to give Telithromycin PIS1M1, Telithromycin PIS1M2, Telithromycin PIS1M3, Telithromycin PIS1M4 and Telithromycin PIS2M1. Endoplasmic Reticulum Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Telithromycin Telithromycin Telithromycin PIS2M1 Telithromycin PIS2M1 Telithromycin PIS4M1 Telithromycin PIS4M1 Telithromycin PIS1M2 Telithromycin PIS2M2 Telithromycin PIS1M1 Urinary Excretion and/or Bile duct Excretion