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Unknown Unknown Unknown Unknown Unknown Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Cytochrome P450 3A4 Salicylamide Salicylamide Salicylamide PIS1M4 Salicylamide PIS1M2 Salicylamide PIS1M2 Salicylamide PIS1M3 Salicylamide PIS1M3 Salicylamide PIS2M1 Salicylamide PIS2M1 Salicylamide PIS1M1 Salicylamide PIS1M4 Heme Heme Heme Heme Heme Urinary Excretion and/or Bile duct Excretion Endoplasmic Reticulum Cytosol Hepatocyte Blood Vessel Liver kidney Bile Duct Blood Vessel Salicylamide undergoes metabolism to give Salicylamide PIS1M1, Salicylamide PIS1M2, Salicylamide PIS1M3, Salicylamide PIS1M4 and Salicylamide PIS2M1. Endoplasmic Reticulum
Endoplasmic Reticulum Endoplasmic Reticulum Unknown Unknown Unknown Unknown Unknown CYP3A4 CYP3A4 CYP3A4 CYP3A4 CYP3A4 Salicylamide Salicylamide Salicylamide PIS1M4 Salicylamide PIS1M2 Salicylamide PIS1M2 Salicylamide PIS1M3 Salicylamide PIS1M3 Salicylamide PIS2M1 Salicylamide PIS2M1 Salicylamide PIS1M1 Salicylamide PIS1M4 Urinary Excretion and/or Bile duct Excretion