PathWhiz

PathWhiz ID	Pathway	Meta Data
PW251361 View Pathway	metabolic 4-Chlorobiphenyl degradation Pseudoxanthomonas spadix 4-chlorobiphenyl, a PCB and environmental pollutant, is degraded by bacteria e.g., Pseudoxanthomonas spadix a source of carbon and energy. 4-Chlorobiphenyl degradation in Pseudoxanthomonas spadix begins with the oxidation of 4-chlorobiphenyl by biphenyl 2,3-dioxygenase small subunit (BphA2) to form an intermediate compound, cis-2,3-Dihydro-2,3-dihydroxy-4'-chlorobiphenyl. This intermediate is then dehydrogenated to 2,3-Dihydroxy-4'-chlorobiphenyl, by 2,3-dihydroxy-2,3-dihydrophenylpropionate dehydrogenase. Subsequently, the compound is converted by 2,3-dihydroxybiphenyl-1,2-dioxygenase to form 2-Hydroxy-6-oxo-6-(4'-chlorophenyl)-hexa-2,4-dienoate, that is further degraded to produce compounds such as pyruvate and acetyl-COA which are essential for glycolysis and citrate cycle. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Julia Wakoli Created On: May 22, 2024 at 13:58 Last Updated: May 22, 2024 at 13:58
PW146983 View Pathway	metabolic 4-Aminohippuric acid Drug Metabolism Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 10, 2023 at 13:35 Last Updated: October 10, 2023 at 13:35
PW002068 View Pathway	metabolic 4-Aminobutanoate Degradation I Escherichia coli Putrescine is an organic chemical produced when amino acids are broken down in organsisms, both living and dead. It can be used as a carbon and nitrogen source in E. coli, and is broken down into gamma-aminobutyric acid (GABA). In this pathway, GABA from putrescine degradation reacts with oxoglutaric acid in a reversible reaction catalyzed by 4-aminobutyrate aminotransferase. This reaction forms succinic acid semialdehyde, as well as L-glutamic acid as a byproduct. Succinic acid semialdehyde is then converted to succinic acid in a reaction catalyzed by succinate-semialdehyde dehydrogenase, using NAD as a cofactor. Succinic acid can then be used by the bacteria in the TCA cycle. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: October 09, 2015 at 15:50 Last Updated: October 09, 2015 at 15:50
PW123551 View Pathway	metabolic 4-Aminobutanoate Degradation I Pseudomonas aeruginosa Putrescine is an organic chemical produced when amino acids are broken down in organsisms, both living and dead. It can be used as a carbon and nitrogen source in E. coli, and is broken down into gamma-aminobutyric acid (GABA). In this pathway, GABA from putrescine degradation reacts with oxoglutaric acid in a reversible reaction catalyzed by 4-aminobutyrate aminotransferase. This reaction forms succinic acid semialdehyde, as well as L-glutamic acid as a byproduct. Succinic acid semialdehyde is then converted to succinic acid in a reaction catalyzed by succinate-semialdehyde dehydrogenase, using NAD as a cofactor. Succinic acid can then be used by the bacteria in the TCA cycle. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: August 12, 2019 at 22:31 Last Updated: August 12, 2019 at 22:31
PW002382 View Pathway	metabolic 4-Aminobutanoate Degradation Saccharomyces cerevisiae GABA(γ-aminobutyric acid) is a non-protein amino acid that can be accumulated via permease-mediated uptake by Uga4p, Put4p, and Gap1p. GABA can also be produced via glutamate degradation by the glutamate decarboxylase, this variant of the pathway includes a 2-oxoglutarate-dependent 4-aminobutyrate transaminase and an NAD+-dependent dehydrogenase. This combination of enzymes has been documented in bacteria and animals and in some plants. Regarding the hydrogenase, NAD-specific variants have been studied from many bacteria, plant and animals. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: miguel ramirez Created On: December 10, 2015 at 12:00 Last Updated: December 10, 2015 at 12:00
PW175957 View Pathway	metabolic 4-(Isopropylamino)diphenylamine Predicted Metabolism Pathway new Homo sapiens Metabolites of 4-(Isopropylamino)diphenylamine are predicted with biotransformer. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Omolola Created On: November 29, 2023 at 12:47 Last Updated: November 29, 2023 at 12:47
PW146791 View Pathway	drug action 4-(Isopropylamino)diphenylamine Drug Metabolism Action Pathway Homo sapiens BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ray Kruger Created On: October 07, 2023 at 19:03 Last Updated: October 07, 2023 at 19:03
PW000698 View Pathway	disease 3-Phosphoglycerate Dehydrogenase Deficiency Homo sapiens 3-Phosphoglycerate dehydrogenase deficiency is a disorder of L-serine biosynthesis that is characterized by congenital microcephaly, psychomotor retardation, and seizures.The disorder is caused by homozygous or compound heterozygous or homozygous mutation in the gene encoding phosphoglycerate dehydrogenase on chromosome 1p12. Defects in the gene lead to a decrease of Glycine and Serine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: WishartLab Created On: June 23, 2014 at 02:39 Last Updated: June 23, 2014 at 02:39
PW121909 View Pathway	disease 3-Phosphoglycerate Dehydrogenase Deficiency Mus musculus 3-Phosphoglycerate dehydrogenase deficiency is a disorder of L-serine biosynthesis that is characterized by congenital microcephaly, psychomotor retardation, and seizures.The disorder is caused by homozygous or compound heterozygous or homozygous mutation in the gene encoding phosphoglycerate dehydrogenase on chromosome 1p12. Defects in the gene lead to a decrease of Glycine and Serine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:50 Last Updated: September 10, 2018 at 15:50
PW122133 View Pathway	disease 3-Phosphoglycerate Dehydrogenase Deficiency Rattus norvegicus 3-Phosphoglycerate dehydrogenase deficiency is a disorder of L-serine biosynthesis that is characterized by congenital microcephaly, psychomotor retardation, and seizures.The disorder is caused by homozygous or compound heterozygous or homozygous mutation in the gene encoding phosphoglycerate dehydrogenase on chromosome 1p12. Defects in the gene lead to a decrease of Glycine and Serine. BioPAX SVG SBGN SBML PWML All files (.zip)	Creator: Ana Marcu Created On: September 10, 2018 at 15:52 Last Updated: September 10, 2018 at 15:52